Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Gene that controls the severity of asthma identified

21.09.2005


Yale School of Medicine researchers identified a gene prevalent in the population that controls the clinical severity of asthma, according to their report in this week’s Proceedings of the National Academy of Sciences.



Richard Bucala, M.D., professor in the Department of Internal Medicine and senior author of the study, said that once you have asthma, there are genes that are going to control how bad it is.

"Asthma patients who have high production variants of the macrophage migration inhibitory factor gene (MIF) are more likely to have severe disease," he said.


Asthma is a clinical syndrome of airway inflammation, excessive response, and airflow obstruction to the lungs. Patients with asthma produce MIF, a gene product that regulates immunity, in their serum and in the fluid that lines their lungs.

The study by Bucala and his colleagues in Dublin, Ireland, included experiments in mice that are resistant to developing asthma because they lack the gene, and an examination of a human population in Dublin chosen for their similar ethnic and geographic identity.

When challenged with a trigger for their asthma attack, the genetically deficient mice had less pulmonary inflammation and lower airway hyper-responsiveness than genetically matched, wild-type control mice. Similarly, in an analysis of 151 Caucasian patients with mild, moderate and severe asthma, there was a significant association between mild asthma and the low expression of MIF.

"These results support an important role for MIF in the pathogenesis of human asthma," Bucala said. "A drug treatment to lower MIF in patients may be beneficial and could be guided by the MIF genotype of affected individuals."

Jacqueline Weaver | EurekAlert!
Further information:
http://www.yale.edu

More articles from Life Sciences:

nachricht Cryo-electron microscopy achieves unprecedented resolution using new computational methods
24.03.2017 | DOE/Lawrence Berkeley National Laboratory

nachricht How cheetahs stay fit and healthy
24.03.2017 | Forschungsverbund Berlin e.V.

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>