Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Breast cancer advance

16.09.2005


A new family of genes could hold the key to winning the battle against breast cancer, according to new research at the University of East Anglia.



Cancer specialists at UEA have discovered that several ‘ADAMTS’ genes are turned off in breast cancer compared to normal breast tissue, while others are switched on. These genes could be targets for the development of ‘smart’ drugs tailored to treat individual patients’ tumours.

The ADAMTS genes are recent additions to a large family known as the metalloproteinases – many of which can break down tissues and have therefore been linked with tumour metastasis, or spread, through the body. However, the ADAMTS group had not previously been linked to the development of breast cancer. These new findings suggest they could become robust ‘markers’, predicting disease outcome in breast cancer patients and identifying those patients most at risk of recurrence of the disease.


Funded by Breast Cancer Campaign, the innovative three-year study has been undertaken by Dr Sarah Porter and Prof Dylan Edwards of UEA’s School of Biological Sciences, using tissue samples from patients at the Norfolk and Norwich University Hospital and a medical centre in Nijmegen in The Netherlands. The findings have just been published in the International Journal of Cancer.

“We are beginning to understand how genes contribute to breast cancer development and I am confident this work will ultimately prove valuable for both diagnosis and treatment of the disease,” said Prof Edwards.

Pamela Goldberg, Breast Cancer Campaign chief executive, said: “The spread of breast cancer around the body is the single most important factor in breast cancer mortality. The findings of this research will play a major role in improving the future of breast cancer treatment which will focus on drug regimes tailored to the individual patient.”

Earlier published work by Dr Porter and Prof Edwards showed that 11 of the 19 ADAMTS genes in humans are significantly altered as breast cancer develops. Their latest research now focuses on two of the genes, ADAMTS8 and ADAMTS15, and has shown that they can help to predict disease outcome in breast cancer patients. These new findings show that differing levels of activity of these genes means that patients can be grouped into one of four categories. These categories could be used to predict the likelihood of the breast cancer recurring. Those in the highest risk category are three times more likely to have a recurrence of breast cancer, and over five times more likely to die from the disease, than patients in the lowest risk category.

The UEA team hope that, in the future, clinicians will look at the levels of ADAMTS genes in a patient’s tumour and be able to prescribe the most effective therapy for treating the disease.

Simon Dunford | alfa
Further information:
http://www.uea.ac.uk

More articles from Life Sciences:

nachricht Navigational view of the brain thanks to powerful X-rays
18.10.2017 | Georgia Institute of Technology

nachricht Separating methane and CO2 will become more efficient
18.10.2017 | KU Leuven

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Osaka university researchers make the slipperiest surfaces adhesive

18.10.2017 | Materials Sciences

Space radiation won't stop NASA's human exploration

18.10.2017 | Physics and Astronomy

Los Alamos researchers and supercomputers help interpret the latest LIGO findings

18.10.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>