Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Compounds found in cruciferous vegetables block lung cancer progression

15.09.2005


A family of compounds found in cruciferous vegetables, such as broccoli, cauliflower, and watercress, blocked lung cancer progression in both animal studies and in tests with human lung cancer cells, report researchers from Georgetown University Medical Center and the Institute for Cancer Prevention.



They say the results, published in a set of papers in the September 15 issue of Cancer Research, suggest that these chemicals -- put into a veggie pill of sorts -- might some day be used to help current and former smokers ward off development of lung cancer, the leading cause of cancer death in Americans.

"These studies provides significant insight into the mechanisms of lung cancer prevention and suggests ways the process can be slowed down after exposure has already occurred," said the study’s principal investigator Fung-Lung Chung, Ph.D., Professor of Oncology in the Lombardi Cancer Center at the Georgetown University Medical Center. He worked with researchers from the Institute for Cancer Prevention, in Valhalla, New York, and with other scientists in Illinois, Minnesota and New York on the studies.


"We still need to do more research, but it may be that an agent containing these ingredients could, to some degree, help protect people who have developed early lung lesions due to smoking," Chung said. "In any case, we know that eating vegetables is generally good for us, and that some studies have shown they help lower a person’s risk of developing cancer."

One of the two new studies being reported was the first to test whether these compounds, derived from naturally occurring isothiocyanates, could have an impact on the stages of cancer development specifically after exposure to cancer-causing elements . To test that, the researchers induced lung tumor development in experimental mice by exposing them to tobacco carcinogens, and then they fed one group of mice the veggie compounds. They found that, indeed, use of the chemicals resulted in a reduced development of benign (harmless) lung tumors to malignant tumors, compared to mice that did not receive the compound.

Chung cautions, however, that it is difficult to draw any direct comparisons between human consumption of these vegetables and the effects seen in the mice studies. "Because the amount of carcinogens we used to induce tumors was very high, we needed to use a very high dose of isothiocyanates to see any effect," he said. "This animal model will give us data for the potential use of such agents in a human clinical trial."

The second new study looked at the effect of the same compound on human lung cancer cells, which were forced to grow quickly (as cancer does) because of insertion of a gene known to be involved in cell growth and regulation. The laboratory test showed that the derivative of isothiocyanate significantly pushed the human lung cells to commit "suicide," compared to cells that did not have the gene, suggesting that its use may stop fast growing lung cancer cells from the outset. This study provides some insight onto "one of the possible mechanisms of action" by which the compounds may offer some protection against lung cancer development, the researchers said.

These studies were continuation of a 20-year research effort by Chung and his team, much of it conducted while Chung was at the Institute for Cancer Prevention before moving to Georgetown University Medical Center. The body of research they have established on the connection between cruciferous vegetables and lung cancer is one of the most detailed available. Chung earlier identified the isothiocyanates may be responsible for the beneficial effects of these vegetables, and he had shown they were effective in hindering development of lung cancer cells.

Cindy Fox Aisen | EurekAlert!
Further information:
http://www.georgetown.edu

More articles from Life Sciences:

nachricht The birth of a new protein
20.10.2017 | University of Arizona

nachricht Building New Moss Factories
20.10.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Terahertz spectroscopy goes nano

20.10.2017 | Information Technology

Strange but true: Turning a material upside down can sometimes make it softer

20.10.2017 | Materials Sciences

NRL clarifies valley polarization for electronic and optoelectronic technologies

20.10.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>