Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Compounds found in cruciferous vegetables block lung cancer progression


A family of compounds found in cruciferous vegetables, such as broccoli, cauliflower, and watercress, blocked lung cancer progression in both animal studies and in tests with human lung cancer cells, report researchers from Georgetown University Medical Center and the Institute for Cancer Prevention.

They say the results, published in a set of papers in the September 15 issue of Cancer Research, suggest that these chemicals -- put into a veggie pill of sorts -- might some day be used to help current and former smokers ward off development of lung cancer, the leading cause of cancer death in Americans.

"These studies provides significant insight into the mechanisms of lung cancer prevention and suggests ways the process can be slowed down after exposure has already occurred," said the study’s principal investigator Fung-Lung Chung, Ph.D., Professor of Oncology in the Lombardi Cancer Center at the Georgetown University Medical Center. He worked with researchers from the Institute for Cancer Prevention, in Valhalla, New York, and with other scientists in Illinois, Minnesota and New York on the studies.

"We still need to do more research, but it may be that an agent containing these ingredients could, to some degree, help protect people who have developed early lung lesions due to smoking," Chung said. "In any case, we know that eating vegetables is generally good for us, and that some studies have shown they help lower a person’s risk of developing cancer."

One of the two new studies being reported was the first to test whether these compounds, derived from naturally occurring isothiocyanates, could have an impact on the stages of cancer development specifically after exposure to cancer-causing elements . To test that, the researchers induced lung tumor development in experimental mice by exposing them to tobacco carcinogens, and then they fed one group of mice the veggie compounds. They found that, indeed, use of the chemicals resulted in a reduced development of benign (harmless) lung tumors to malignant tumors, compared to mice that did not receive the compound.

Chung cautions, however, that it is difficult to draw any direct comparisons between human consumption of these vegetables and the effects seen in the mice studies. "Because the amount of carcinogens we used to induce tumors was very high, we needed to use a very high dose of isothiocyanates to see any effect," he said. "This animal model will give us data for the potential use of such agents in a human clinical trial."

The second new study looked at the effect of the same compound on human lung cancer cells, which were forced to grow quickly (as cancer does) because of insertion of a gene known to be involved in cell growth and regulation. The laboratory test showed that the derivative of isothiocyanate significantly pushed the human lung cells to commit "suicide," compared to cells that did not have the gene, suggesting that its use may stop fast growing lung cancer cells from the outset. This study provides some insight onto "one of the possible mechanisms of action" by which the compounds may offer some protection against lung cancer development, the researchers said.

These studies were continuation of a 20-year research effort by Chung and his team, much of it conducted while Chung was at the Institute for Cancer Prevention before moving to Georgetown University Medical Center. The body of research they have established on the connection between cruciferous vegetables and lung cancer is one of the most detailed available. Chung earlier identified the isothiocyanates may be responsible for the beneficial effects of these vegetables, and he had shown they were effective in hindering development of lung cancer cells.

Cindy Fox Aisen | EurekAlert!
Further information:

More articles from Life Sciences:

nachricht Novel mechanisms of action discovered for the skin cancer medication Imiquimod
21.10.2016 | Technische Universität München

nachricht Second research flight into zero gravity
21.10.2016 | Universität Zürich

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Resolving the mystery of preeclampsia

21.10.2016 | Health and Medicine

Stanford researchers create new special-purpose computer that may someday save us billions

21.10.2016 | Information Technology

From ancient fossils to future cars

21.10.2016 | Materials Sciences

More VideoLinks >>>