Researchers at the University of Dundee have discovered new levels of complexity in the regulation of the tumour suppressor gene p53, findings which could have a significant impact on the identification of patients at risk of developing aggressive cancer and in determining more efficient drug treatments.
The research has been led by Professor Sir David Lane and Dr Jean-Christophe Bourdon of the Cancer Research UK Cell Transformation Group at the University of Dundee. Prof Lane famously discovered the p53 protein, and continues to lead cutting edge research in this field.
The new findings, which are to be published on the 15 September in the journal, "Genes and Development", show that the p53 gene, the most frequently inactivated gene in human cancer, does not produce only one unique p53 protein as previously thought, but at least six different p53 proteins (isoforms). They also established that expression of p53 isoforms is abnormal in breast tumours.
Roddy Isles | alfa
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