Who works together with whom? This is the question scientists at the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch have investigated with regard to human proteins. The answer can be found within a map – the first one in international research – showing 3,186 interactions between 1,705 human proteins. Among them: 531 previously unknown interactions involving 195 disease proteins, highly relevant for medical research.
“We have laid the foundation for a comprehensive connection scheme of the human body. The map helps us understand the functions of proteins and the complex processes in our cells,” explains Professor Erich Wanker, who directed the study.
The work of Professor Wanker and Dr. Ulrich Stelzl, to which scientists from the Max Planck Institute for Molecular Genetics (Berlin) and the German Resource Center for Genome Research GmbH (Heidelberg) contributed, has now been published in the online edition of Cell* (DOI: 10.1016/S0092867405008664). The researchers were able to conduct the project, which is the first extensive human protein network to be published, with the support of the National Genome Research Network (NGFN) – a large scale biomedical program initiated by the German Federal Ministry for Education and Research (BMBF). The NGFN enables scientists to systematically investigate human genes and proteins and their role in health and disease.
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