Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers find human brain still evolving

09.09.2005


Human evolution, University of Chicago researchers report, is still under way in what has become our most important organ: the brain. In two related papers, published in the September 9, 2005, issue of Science, they show that two genes linked to brain size are rapidly evolving in humans.



"Our studies indicate that the trend that is the defining characteristic of human evolution--the growth of brain size and complexity--is likely still going on," said lead researcher for both papers Bruce Lahn, PhD, assistant professor of human genetics at the University of Chicago and an investigator at the Howard Hughes Medical Institute. "Meanwhile, our environment and the skills we need to survive in it are changing faster then we ever imagined. I would expect the human brain, which has done well by us so far, will continue to adapt to those changes."

Evolution, Lahn said, doesn’t occur at the species level. Rather, some individuals first acquire a specific genetic mutation; and because that variant confers on those who bear it a greater likelihood of survival, it then spreads in the population. "We’re seeing two examples of such a spread in progress," he said. "In each case, it’s a spread of a new genetic variant in a gene that controls brain size. This variant is clearly favored by natural selection."


Lahn previously showed that there was accelerated evolution in humans among numerous genes, including microcephalin and abnormal spindle-like microcephaly-associated (ASPM). Both of these genes regulate brain size, and therefore "were good candidates to look for signatures of selection. We indeed found such signatures when we compared humans to other species," he said. "As a natural extension of that, we asked, could it be that selection on these genes is still ongoing in humans?"

In the two Science papers, the researchers looked at variations of microcephalin and ASPM within modern humans. They found evidence that the two genes have continued to evolve. For each gene, one class of variants has arisen recently and has been spreading rapidly because it is favored by selection. For microcephalin, the new variant class emerged about 37,000 years ago and now shows up in about 70 percent of present-day humans. For ASPM, the new variant class arose about 5,800 years ago and now shows up in approximately 30 percent of today’s humans. These time windows are extraordinarily short in evolutionary terms, indicating that the new variants were subject to very intense selection pressure that drove up their frequencies in a very brief period of time--both well after the emergence of modern humans about 200,000 years ago.

Each variant emerged around the same time as the advent of "cultural" behaviors. The microcephalin variant appears along with the emergence of such traits as art and music, religious practices, and sophisticated tool-making techniques--which date back to about 50,000 years ago. The ASPM variant coincides with the oldest-known civilization, Mesopotamia, which dates back to 7000 BC. "Microcephalin," the authors wrote in one of the papers, "has continued its trend of adaptive evolution beyond the emergence of anatomically modern humans. If selection indeed acted on a brain-related phenotype, there could be several possibilities, including brain size, cognition, personality, motor control or susceptibility to neurological/psychiatric diseases."

"The next step is to find out what biological difference imparted by this genetic difference causes selection to favor that variation over the others," Lahn said.
Both microcephalin and ASPM have numerous genetic variations. The authors show that certain variants are subject to very strong positive selection over others.

To determine the variation frequency of the two genes, the researchers surveyed more than 1,000 individuals representing 59 ethnic populations worldwide. For each gene, the scientists identified a large number of haplotypes, or variant copies. They found that one class of haplotypes, called haplogroup D, shows two distinct characteristics. First, they are very young. Because not enough evolutionary time has passed since the first copy of these variants appeared for them to diversify, all the haplogroup D variants are nearly identical. Second, despite recent emergence they have spread rapidly. "In a very short period of time, this class of variants arose from a single copy to many copies. That implies that this must have happened because of positive selection," Lahn said, pointing out that it’s statistically unlikely for a haplogroup this young to have such high frequency due merely to random genetic drift.

The team also observed geographic differences. For haplogroup D of ASPM, they found that it occurs more frequently in Europeans and surrounding populations including, North Africans, Middle Easterners, and South Asians, and at a lower incidence in East Asians, New World Indians and sub-Saharan Africans. For microcephalin, the researchers found that haplogroup D is more abundant in populations outside of sub-Saharan Africa.
The biochemical functions of these two genes are not fully understood. There is, however, some information as to what they do. Mutations that render either gene completely nonfunctional in humans cause microcephaly, a medical condition in which the brain is much smaller than normal. In many cases there are often no other abnormalities, which indicates that these two genes play an important role in brain size.

A series of studies suggest that there is some correlation between brain size and intelligence, but with some exceptions. Although, on average, a man’s brain is 3 to 4 percent larger than a woman’s, both sexes score similarly on IQ tests. Lahn also points out that "brain size is very heritable. Bad nutrition is typically not a factor; the brain is very privileged within the body." The researchers emphasize that very little is known about the impact of these variants. They may not have anything to do with cognition or intelligence. "Just because these genes are still evolving, doesn’t necessarily mean they make you any smarter," Lahn said. "We’ve evolved genes for selfishness, violence, cruelty--all of which are in place because they may make survival easier. But in today’s society, they’re certainly not condoned."

Lahn and colleagues stress these studies only examine two genes, and that the genetic variations within a population are often almost as great as the differences between groups. "If we look at multiple genes, the ethnic variations--such as the ones we found--are likely to be counterbalanced by other differences," Lahn said. "It just happens that we looked at two genes for which the variants favored by selection have a higher frequency in some populations, such as Europeans. It might be that for the next two brain size genes we find, the variants favored by selection will have a higher frequency in Asians or Africans." Scientists know of about a half dozen other genes that are primarily linked to brain size and several others that may also play a role in regulating brain size. According to Lahn, these are all primary candidates for learning more about human evolution.

HHMI funded both of these studies. First author for the ASPM paper is Nitzan Mekel-Bobrov, and first author for the microcephalin paper is Patrick Evans, both of whom are graduate students in Lahn’s lab.

Catherine Gianaro | EurekAlert!
Further information:
http://www.uchospitals.edu

More articles from Life Sciences:

nachricht Researchers identify potentially druggable mutant p53 proteins that promote cancer growth
09.12.2016 | Cold Spring Harbor Laboratory

nachricht Plant-based substance boosts eyelash growth
09.12.2016 | Fraunhofer-Institut für Angewandte Polymerforschung IAP

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>