At the Institut Curie, the CNRS team of Yohanns Bellaïche has just discovered a new cellular component that participates in the organization of cells in the epithelium. This tissue, which forms a barrier between our body and the outside world, is an extremely coherent structure of myriad cells that fit together according to very precise rules. This cohesion holds together the tissues that compose the organs and controls the "comings and goings" of various substances between the outside world and our body.
When cellular adhesives come unstuck… One of the components of the exocyst has been inactivated in these cells. The two cellular adhesives – cadherin (pink) and _-catenin (blue) – are dispersed through the cytoplasm instead of being localized essentially at the membranes, to form the intercellular junction. © J. Langevin/Institut Curie
The Institut Curie CNRS researchers’ discovery sheds light on how cells "stick together", thereby ensuring the cohesion needed for proper bodily functioning, but also clarifies the problems that may arise if this cellular cohesion is impaired. When tumor cells no longer stick together, they can move around and invade other tissues. This leads to a risk of propagation via metastases, which complicates the treatment of cancer.
These results are published in the September 2005 issue of Developmental Cell.
The epithelium lines all the cavities of our body. Like a border, it separates inside from out: the skin isolates us from the outside world, epithelial cells lining the small intestine separate the intestinal cavity – the "lumen" – from the rest of the body. The epithelium also regulates "toing and froing" across the border, since its cells are polar – they have a sort of compass which tells them which way is out and which in:
Novel mechanisms of action discovered for the skin cancer medication Imiquimod
21.10.2016 | Technische Universität München
Second research flight into zero gravity
21.10.2016 | Universität Zürich
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...
'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.
Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
21.10.2016 | Health and Medicine
21.10.2016 | Information Technology
21.10.2016 | Materials Sciences