At the Institut Curie, the CNRS team of Yohanns Bellaïche has just discovered a new cellular component that participates in the organization of cells in the epithelium. This tissue, which forms a barrier between our body and the outside world, is an extremely coherent structure of myriad cells that fit together according to very precise rules. This cohesion holds together the tissues that compose the organs and controls the "comings and goings" of various substances between the outside world and our body.
When cellular adhesives come unstuck… One of the components of the exocyst has been inactivated in these cells. The two cellular adhesives – cadherin (pink) and _-catenin (blue) – are dispersed through the cytoplasm instead of being localized essentially at the membranes, to form the intercellular junction. © J. Langevin/Institut Curie
The Institut Curie CNRS researchers’ discovery sheds light on how cells "stick together", thereby ensuring the cohesion needed for proper bodily functioning, but also clarifies the problems that may arise if this cellular cohesion is impaired. When tumor cells no longer stick together, they can move around and invade other tissues. This leads to a risk of propagation via metastases, which complicates the treatment of cancer.
These results are published in the September 2005 issue of Developmental Cell.
The epithelium lines all the cavities of our body. Like a border, it separates inside from out: the skin isolates us from the outside world, epithelial cells lining the small intestine separate the intestinal cavity – the "lumen" – from the rest of the body. The epithelium also regulates "toing and froing" across the border, since its cells are polar – they have a sort of compass which tells them which way is out and which in:
Researchers develop eco-friendly, 4-in-1 catalyst
25.04.2017 | Brown University
Transfecting cells gently – the LZH presents a GNOME prototype at the Labvolution 2017
25.04.2017 | Laser Zentrum Hannover e.V.
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
25.04.2017 | Physics and Astronomy
25.04.2017 | Materials Sciences
25.04.2017 | Life Sciences