Bacterial meningitis is the most common nervous system infection and a major cause of childhood death. In a new study appearing in the September 1 print issue of The Journal of Clinical Investigation, Kelly Doran and colleagues from UCSD investigate the mechanisms responsible for the penetration of the human blood-brain barrier (BBB) by Group B Streptococcus (GBS), the bacteria that causes meningitis in newborn infants.
The authors find a novel GBS gene, called iagA, which helps the bacteria invade the normally shield-like brain endothelial cells of the BBB. An iagA mutant showed decreased invasion through these cells and reduced the development of meningitis and lethality in vivo. Deletion of iagA did not affect other key steps in the pathogenesis of GBS meningitis, including bacterial survival. Thus iagA specifically promotes endothelial cell uptake of the pathogen. The iagA gene product seems to synthesize a glycolipid anchor that facilitates the bacteria’s interaction with the host cell.
Stacie Bloom | EurekAlert!
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More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
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Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
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The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
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The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
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