25 years after the initial discovery of p53, Dr. David Lane and colleagues at the University of Dundee have discovered multiple isoforms of the p53 tumor suppressor protein.
Their paper, which will be released online ahead of print in Genes & Development, establishes that, like the other p53 family members p63 and p73, p53 exists in human cells in at least six different isoforms. Dr. Lane and colleagues identified a heretofore unrecognized internal promoter and alternative splice exons in p53 mRNA.
While further research is needed to delineate how the various p53 isoforms affect p53 tumor suppressor activity, the scientists did establish that some p53 isoforms can modulate p53 transcriptional activity and p53-induced cell death. Interestingly, Prof. Lane and colleagues observed that p53 isoforms are abnormally expressed in breast tumors presenting no mutation of the p53 gene. David Lane and Jean-Christophe Bourdon, group leader in David Lanes laboratory, consider the discovery of p53 isoforms to be "a major breakthrough in the understanding of cancer formation.
Heather Cosel | EurekAlert!
At last, butterflies get a bigger, better evolutionary tree
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Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.
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Let’s say the armrest is broken in your vintage car. As things stand, you would need a lot of luck and persistence to find the right spare part. But in the world of Industrie 4.0 and production with batch sizes of one, you can simply scan the armrest and print it out. This is made possible by the first ever 3D scanner capable of working autonomously and in real time. The autonomous scanning system will be on display at the Hannover Messe Preview on February 6 and at the Hannover Messe proper from April 23 to 27, 2018 (Hall 6, Booth A30).
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