An unusual type of antibiotic being developed by chemists at Notre Dame University shows promise in defeating deadly "superbugs" — highly drug-resistant staph bacteria that are an increasing source of hospital-based infections. The novel antibiotics, which could some day save lives, were described today at the 230th national meeting of the American Chemical Society, the world’s largest scientific society.
The new antibiotics are synthetic forms of cephalosporin, a broad-spectrum antibiotic closely related to penicillin. They appear to kill bacteria by masquerading as components of the bacterial cell wall in order to deactivate an enzyme that functions as a key bacterial defense mechanism, the researchers say. In preliminary lab tests, the new antibiotics — the first to exhibit this mimicry mechanism — were effective against vancomycin-resistant MRSA, a rare but extremely deadly staph strain for which treatment options are extremely limited, they say.
"We are the first to demonstrate this unique strategy, which could provide a new line of defense against the growing problem of antibiotic resistance," says study leader Shahriar Mobashery, Ph.D., a chemist at the university. "As scientists, we’re trying to stay one step ahead of the bacteria. The more strategies there are to fight resistance, the better."
Transforming plant cells from generalists to specialists
07.12.2016 | Duke University
What happens in the cell nucleus after fertilization
06.12.2016 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
07.12.2016 | Materials Sciences
07.12.2016 | Earth Sciences
07.12.2016 | Earth Sciences