An unusual type of antibiotic being developed by chemists at Notre Dame University shows promise in defeating deadly "superbugs" — highly drug-resistant staph bacteria that are an increasing source of hospital-based infections. The novel antibiotics, which could some day save lives, were described today at the 230th national meeting of the American Chemical Society, the world’s largest scientific society.
The new antibiotics are synthetic forms of cephalosporin, a broad-spectrum antibiotic closely related to penicillin. They appear to kill bacteria by masquerading as components of the bacterial cell wall in order to deactivate an enzyme that functions as a key bacterial defense mechanism, the researchers say. In preliminary lab tests, the new antibiotics — the first to exhibit this mimicry mechanism — were effective against vancomycin-resistant MRSA, a rare but extremely deadly staph strain for which treatment options are extremely limited, they say.
"We are the first to demonstrate this unique strategy, which could provide a new line of defense against the growing problem of antibiotic resistance," says study leader Shahriar Mobashery, Ph.D., a chemist at the university. "As scientists, we’re trying to stay one step ahead of the bacteria. The more strategies there are to fight resistance, the better."
New risk factors for anxiety disorders
24.02.2017 | Julius-Maximilians-Universität Würzburg
Stingless bees have their nests protected by soldiers
24.02.2017 | Johannes Gutenberg-Universität Mainz
In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".
Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
24.02.2017 | Life Sciences
24.02.2017 | Life Sciences
24.02.2017 | Trade Fair News