Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Virginia Tech group adds tools to DNA-targeted anti-cancer drugs

29.08.2005


Chemistry and biology researchers at Virginia Tech have enhanced the abilities of the molecules they are creating to deliver killing blows to cancer cells. The man-made molecular complexes enter cancer cells and, when signaled, deliver killing medicine or cause the cell to change. The new supermolecules have more units that will absorb light – providing more control over the range of light frequencies that can be included and excluded as signals and the responses.



Karen Brewer, professor of chemistry, will give an invited talk, and her students will present a number of posters at the American Chemical Society (ACS) 230th annual meeting in Washington, D.C., Aug. 28 through Sept. 1 to explain their discoveries and applications.

Many scientists are racing to create ways to deliver cancer-killing drugs to tumors without harming surrounding tissue. At ACS meetings in August 2004 and March 2005, Brewer and her team announced the creation of molecular assemblies that solved two challenges facing photodynamic therapy, or activating drug delivery devices with light. The Brewer group’s systems could be activated by visible light in the therapeutic range – a wavelength not blocked or reflected by tissue. The systems also were able to operate without oxygen.


The group now has more kinds of supramolecular assemblies that absorb therapeutic light and they are adding units to the structure. For instance, they added platinum, a metal with anticancer activity because it binds to DNA inhibiting cell replication. "Using platinum assures that we are activating complexes that are already attached to the target," Brewer said. "The previous systems had an association with DNA but could release, which might result in an impact on other parts of the cell."

Because the therapeutic complexes only activate with visible light, the researchers are now able to add a luminescent tag that glows in the presence of ultra violet (UV) light. "The UV light does not activate the system but will allow us to see such things as how the assembly enters cells and how much of the drug reaches the DNA," Brewer said. "It is a common practice in the medical field to use luminescent dyes to study cells, so pathology labs will have the equipment needed to monitor drug delivery.

Brewer is giving her invited talk, "Applications of mixed-metal supramolecular complexes in the development of chemotherapeutic and photodynamic therapy agents" (INOR 219), at 9:15 a.m. Monday Aug. 29, in room 145B of the Washington, D.C., Convention Center. She will talk about adding functionality to the group’s supramolecular assemblies.

Co-authors of the research are Matthew T. Mongelli, of Maywood, N.J., post doctoral associate in chemistry; Virginia Tech chemistry undergraduate students Jerita Dubash, of Ashburn, Va., and Matthew Jeletic, of Centreville, Va., graduate students David F. Zigler, of Sterling, Ill., Julie Heinecke, of Powhatan, Va., and Ran Miao, of Zhangzhou City, China, and biology professor Brenda S. J. Winkel.

In addition, members of the Virginia Tech group are presenting several posters related to the photodynamic therapy research.

Three posters will be available from 7 to 9 p.m. Sunday, Aug. 28. Dubash will present "Time dependent photochemical studies of Rh centered mixed-metal supramolecular complexes which photocleave DNA" (INOR 136), co-authored by Mongelli, Winkel, and Brewer. Heinecke will present "Using 31P NMR and a phosphine tag to monitor stereochemistry and reactivity of Ru(II) light absorbing units in supramolecular assemblies" (INOR 133), co-authored by Mongelli and Brewer. And Zigler will present "Luminescence tagging of 2,2’-bipyridine complexes of Fe(II): Synthesis and metal binding studies of 4-[N-(2-anthryl)amido]-4’-methyl-2,2’-bipyridine" (INOR 141), co-authored by graduate students Mark Elvington and Jared Brown and Brewer.

At the SciMix poster session from 8 to 10 p.m. Monday, Aug. 29, Mongelli will present "Tuning visible light initiated bioreactivity of mixed metal supramolecular complexes by subunit variation" (INOR 96), co-authored by Dubash, Jeletic, Winkel, and Brewer.

And from 7 to 9 p.m. Tuesday, Aug. 30, there will be two posters from the Brewer group. Miao will present "Dictating spatial organization of acceptor and donor orbitals in mixed-metal:mixed-ligand supramolecular complexes" (INOR 392), co-authored by Brewer. And Jeletic will present "Osmium(II) chromophores containing 2,2’:6’,2"-terpyridine and 2,3-bis(2-pyridyl)pyrazine and their use in the construction of supramolecular complexes" (INOR 385), co-authored by Mongelli and Brewer.

All of the poster sessions are in the Washington, D.C., Convention Center Hall A.

Brewer’s photodynamic therapy agent research has been funded by the National Science Foundation (CHE-0408445). Brewer’s group is working in collaboration with Theralase Technologies Inc., a medical laser company in Canada that holds the license on the patented systems.

Susan Trulove | EurekAlert!
Further information:
http://www.vt.edu

More articles from Life Sciences:

nachricht Symbiotic bacteria: from hitchhiker to beetle bodyguard
28.04.2017 | Johannes Gutenberg-Universität Mainz

nachricht Nose2Brain – Better Therapy for Multiple Sclerosis
28.04.2017 | Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik IGB

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Fighting drug resistant tuberculosis – InfectoGnostics meets MYCO-NET² partners in Peru

28.04.2017 | Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

 
Latest News

Wireless power can drive tiny electronic devices in the GI tract

28.04.2017 | Medical Engineering

Ice cave in Transylvania yields window into region's past

28.04.2017 | Earth Sciences

Nose2Brain – Better Therapy for Multiple Sclerosis

28.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>