Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Australian-based research team finds the malaria parasite’s ’housebreaking tool’

29.08.2005


Plasmodium falciparum, the most lethal malaria parasite, is a housebreaking villain of the red blood cell world. Like a burglar searching for a way in to his targeted premises, the parasite explores a variety of potential entry points to invade the red blood cells of its human victims. When a weak point is found, the intrusion proceeds.



Scientists have known about the parasite’s housebreaking habit for a decade, but just how it breaks in to blood cells has been unknown.

Now, an international team of scientists, led by WEHI’s Professor Alan Cowman, has discovered the gene - known as PfRh4 - that the parasite uses as a tool to switch between potential invasion points. More specifically, the gene provides the parasite with the ability to switch from receptors on red blood cells that contain sialic acid to those that do not.


In effect, if the gene finds all the doors locked, then it will try all the windows until it finds one it can force open.

The team who performed the research work consisted of Janine Stubbs, Ken Simpson, Tony Triglia, David Plouffe, Christopher J. Tonkin, Manoj T. Duraisingh, Alexander G. Maier and Elizabeth Winzeler. Professor Cowman and his team at WEHI worked with researchers from the Scripps Research Institute (TSRI) in La Jolla, California and the Genomics Institute of the Novartis Research Foundation in San Diego, California.

This discovery made by the group will have a profound impact upon the design of new anti-malarial vaccines, since the inactivation of this single protein could block multiple entry points currently open to the parasite.

Professor Cowman is a Howard Hughes Medical Institute international research scholar. The results of the new study are published in the 26 August 2005 issue of the prestigious journal, Science.

Brad Allen | EurekAlert!
Further information:
http://www.researchaustralia.com.au
http://www.wehi.edu.au

More articles from Life Sciences:

nachricht New risk factors for anxiety disorders
24.02.2017 | Julius-Maximilians-Universität Würzburg

nachricht Stingless bees have their nests protected by soldiers
24.02.2017 | Johannes Gutenberg-Universität Mainz

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>