A forthcoming paper in the international, open-access journal PLoS Medicine makes the strongest association yet between a newly identified virus and the pediatric respiratory disease commonly known as croup. Following their recent description of the coronavirus HCoV-NL63, Lia van der Hoek and colleagues suggest this is one of the most frequently detected viruses in children with lower respiratory tract infections (LRTIs). These infections are estimated by the World Health Organization to be responsible for one fifth of all deaths in children under five years old.
The team, including researchers from University Medical Centres in Amsterdam, Bochum and Freiberg, determined the incidence of this novel virus in a sample of children under three years old with such respiratory infections. Nine hundred and forty nine samples of nasopharyngeal secretions were collected from both hospitalized patients and outpatients in four different regions of Germany. The study found that forty-nine samples (5.2%) were positive for the virus HCoV-NL63 overall, with a greater incidence in outpatients (7.9%) than hospitalized patients (3.2%). Co-infection with two other viruses also known to be prominent in the cause of LRTIs, was also frequently observed.
The researchers also investigated the occurrence of HCoV-NL63 in cases of respiratory disease where no other virus could be detected. Here, a strong relationship with the clinical symptoms associated with croup was apparent: 43% of the HCoV-NL63 positive patients with high HCoV-NL63 load and absence of co-infection had croup, compared with 6% of HCoV-NL63 negative patients. Previous studies have reported trends in croup, such as the relative susceptibility of boys to the disease, its peak occurrence in the second year of life and its predominance in late autumn and earlier winter, that are matched by patterns of HCoV-NL63 occurrence.
Fingerprint' technique spots frog populations at risk from pollution
27.03.2017 | Lancaster University
Parallel computation provides deeper insight into brain function
27.03.2017 | Okinawa Institute of Science and Technology (OIST) Graduate University
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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