Signs of heart failure may be in the blood. Cardiac researchers at Jefferson Medical College have found an enzyme in the blood that could be a potential marker for heart failure.
A team of scientists led by Walter Koch, Ph.D., director of the Center for Translational Medicine in the Department of Medicine in Jefferson Medical College of Thomas Jefferson University in Philadelphia, previously showed that an enzyme called GRK2 or beta-adrenergic kinase (ßARK1) is critically important in heart function. It is increased in failing human hearts and contributes to the loss of the heart’s contractile strength during the development of heart failure. Decreasing or inhibiting the enzyme reversed heart failure in laboratory tests.
Now, Dr. Koch, who is W.W. Smith Professor of Medicine at Jefferson Medical College, and his co-workers have shown, using tissue samples from heart failure patients, that they could track heart levels of GRK2 in the blood.
Steve Benowitz | EurekAlert!
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