Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Scientists discover gene that controls speed of tuberculosis development

17.08.2005


Scientists at the MUHC have discovered a gene that controls the speed at which patients develop tuberculosis--the first time such a gene has been discovered for this disease. The new study published in the Proceedings of the National Academy of Science (PNAS) this week provides a new view of the mechanisms underlying the development of tuberculosis and may contribute to public health efforts aimed at containing the disease.



"About one-third of the world’s population is infected by Mycobacterium tuberculosis--the bacteria responsible for tuberculosis," says Dr. Erwin Schurr, a molecular geneticist at the Centre for the Study of Host Resistance at the MUHC, and the study’s principal investigator. "Of the estimated two billion people infected, only 5%-10% actually develop tuberculosis disease in their lifetime--the other 90%-95% appear to be able to contain the infection in a dormant state, so that they do not become ill." Dr. Schurr has spent the past 5 years researching why and how this happens.

The new research focused on NRAMP1--a gene already known to be involved in many other illnesses, including diseases as diverse as leprosy and rheumatoid arthritis. "We discovered that variants (alleles) of the NRAMP1 gene control the speed at which tuberculosis develops, rather than whether or not it will develop at all," says Dr. Schurr. "This is the first time a gene has been shown to control the time frame between initial infection and the disease." Certain factors are already known to increase the speed at which people develop tuberculosis. "HIV and tuberculosis are synergistic partners in crime for example," says Dr. Schurr. "They appear to accelerate disease progression when they occur together."


"Understanding the basic pathways of pathogenesis offers new targets and policies for disease prevention," notes Dr. Emil Skamene, Scientific Director of the Research Institute of the MUHC. "Academic hospitals such as the MUHC combine scientific research, technology and clinic expertise, enabling scientific breakthroughs to be developed into treatments and cures that directly benefit patients."

Ian Popple | EurekAlert!
Further information:
http://www.muhc.mcgill.ca

More articles from Life Sciences:

nachricht Decoding the genome's cryptic language
27.02.2017 | University of California - San Diego

nachricht New risk factors for anxiety disorders
24.02.2017 | Julius-Maximilians-Universität Würzburg

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Safe glide at total engine failure with ELA-inside

On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded after a glide flight with an Airbus A320 in ditching on the Hudson River. All 155 people on board were saved.

On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded...

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

New pop-up strategy inspired by cuts, not folds

27.02.2017 | Materials Sciences

Sandia uses confined nanoparticles to improve hydrogen storage materials performance

27.02.2017 | Interdisciplinary Research

Decoding the genome's cryptic language

27.02.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>