Researchers at the University of Illinois at Chicago have identified an elusive subunit of a neurotransmitter receptor found in both humans and the much-studied laboratory nematode C. elegans which may open new pathways of research on muscle function.
The neurotransmitter acetylcholine binds to two different nicotinic receptors at the nematodes neuromuscular junctions, causing them to contract. Previously, researchers knew the subunit composition only of the levamisole-sensitive acetylcholine receptors. In the second, levamisole-insensitive acetylcholine receptors, a subunit called acetylcholine receptor 16, or ACR-16, has now been identified as necessary for this receptors contribution to muscle contraction.
Janet Richmond, assistant professor of biological sciences at UIC, along with graduate students Denis Touroutine and Anna Burdina, reported the findings in the July 22 issue of the Journal of Biological Chemistry. The research also drew on bioinformatic data provided by David Miller, associate professor of cell and developmental biology at Vanderbilt University, and work by his graduate students Rebecca Fox and Stephen Von Stetina.
Paul Francuch | EurekAlert!
Nerves control the body’s bacterial community
26.09.2017 | Christian-Albrechts-Universität zu Kiel
Ageless ears? Elderly barn owls do not become hard of hearing
26.09.2017 | Carl von Ossietzky-Universität Oldenburg
Graphene is up to the job
A warming planet
19.09.2017 | Event News
12.09.2017 | Event News
06.09.2017 | Event News
26.09.2017 | Life Sciences
26.09.2017 | Physics and Astronomy
26.09.2017 | Information Technology