In a paper in this months PLoS Medicine, researchers from the Genome Institute of Singapore describe the identification of a human cellular protein that has a significant effect on the replication efficiency of Hepatitis B virus. Lisa F. P. Ng and colleagues found the protein--hnRNPK--when they noted an association between one particular sequence in the Hepatitis B virus and high levels of the virus in some infected patients. They discovered that how well the virus replicated is determined by a combination of sequence differences of the virus and how well hnRNPK binds to the viral DNA.
Hepatitis B is a serious global public health problem; more than 350 million people have lifelong infections. Chronically infected people are at high risk of death from cirrhosis of the liver and liver cancer, which both kill about 1 million people each year. Current antiviral therapies include lamivudine and alpha-interferon which also suppress viral replication by attacking the virus itself, but the identification of the action of this protein offers new therapeutic opportunities by targeting the human proteins that help the virus to replicate.
Rutgers scientists discover 'Legos of life'
23.01.2018 | Rutgers University
Researchers identify a protein that keeps metastatic breast cancer cells dormant
23.01.2018 | Institute for Research in Biomedicine (IRB Barcelona)
Physicists have developed a technique based on optical microscopy that can be used to create images of atoms on the nanoscale. In particular, the new method allows the imaging of quantum dots in a semiconductor chip. Together with colleagues from the University of Bochum, scientists from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute reported the findings in the journal Nature Photonics.
Microscopes allow us to see structures that are otherwise invisible to the human eye. However, conventional optical microscopes cannot be used to image...
On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.
We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...
What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
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