A therapeutic approach for battling cancer that is based on infection with a specially designed virus similar to the one that causes the common cold has shown promise in clinical trials. Now, new research suggests that fever might be a useful weapon in the fight as well. The study, published in the July issue of Cancer Cell, demonstrates that tumor cells are even more sensitive to viral therapy after they have been incubated at an elevated temperature. The findings could have a significant impact on the future success of viral strategies for cancer therapy.
ONYX-015 is a mutated adenovirus that undergoes selective replication in tumor cells until the cells become so full of virus that they burst and die. The virus is modified so that it only copies itself in tumor cells and is safe for normal cells. In clinical trials, ONYX-015 was a successful therapy for many cancer patients, but the success varied considerably for reasons that were not well understood. Dr. Clodagh C. OShea and colleagues from the Cancer Research Institute at the University of California, San Francisco examined why ONYX-015 did not undergo replication in some cancer cells and if it might be possible to sensitize tumor cells to ONYX-015 therapy.
The researchers demonstrated that resistant tumor cells fail to complete an RNA export function that is necessary for ONYX-015 replication. Interestingly, when a cellular heat shock response was induced in the resistant tumor cells, either pharmacologically or by incubating the cells at an elevated temperature similar to that experienced by humans when they have a fever, the RNA export function was restored. Therefore, induction of the heat shock response could rescue ONYX-015 replication in resistant tumor cells.
Heidi Hardman | EurekAlert!
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The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
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Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
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In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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