MADISON-Boosting levels of two critical proteins that normally shut down during Huntingtons disease, researchers at the University of Wisconsin-Madison and the Cold Spring Harbor Laboratory have cured fruit flies of the genetic, neurodegenerative condition.
Forms of the same proteins-known in short form as CREB and HSP-70--exist in all cells, including those of humans.
The study results, published online today by the Proceedings of the National Academy of Sciences, were a "logical finding" because of a growing body of work in the area, says senior author Jerry Yin, a UW-Madison molecular geneticist. Scientists previously knew, for example, that hiking the activity of either CREB or HSP-70 lessened symptoms in mice or flies with Huntingtons disease.
Jerry Yin | EurekAlert!
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