A new study in the July 18 issue of The Journal of Experimental Medicine shows that gold-colored bacteria are more harmful than their unpigmented relatives. A group of scientists led by Victor Nizet (UCSD, San Diego, CA) have discovered that the molecules that give certain bugs their color also help them resist attack by immune cells called neutrophils.
Scientists and clinicians have known for many years that gold-colored strains of a bacterium called Staphylococcus aureus tend to be cause more disease than colorless strains. The color of these bugs comes from anti-oxidant molecules called carotenoids. Similar molecules also give carrots their color and are often touted for their ability to boost the immune system.
Nizet and colleagues now show that these pigmented molecules help S. aureus defuse damaging molecules that are produced by neutrophils in order to kill the bacteria. When the researchers removed the carotenoids from the bacteria, they became more vulnerable to immune attack. Nizet suggests that drugs that inhibit carotenoid synthesis might be useful for treating S. aureus infections, which can quickly develop resistance to traditional antibiotics.
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Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
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Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.
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In an article that appears in the journal “Review of Modern Physics”, researchers at the Laboratory for Attosecond Physics (LAP) assess the current state of the field of ultrafast physics and consider its implications for future technologies.
Physicists can now control light in both time and space with hitherto unimagined precision. This is particularly true for the ability to generate ultrashort...
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19.04.2018 | Materials Sciences
19.04.2018 | Physics and Astronomy
19.04.2018 | Physics and Astronomy