Patients suffering from oral cancer have increased levels of certain bacteria in their saliva, according to new research published today in the Open Access journal, Journal of Translational Medicine. Six common species of bacteria were found at significantly higher levels in the saliva of patients with oral squamous cell carcinoma (OSCC) than in the saliva of healthy individuals. The researchers were able to use three of the six species as a diagnostic tool to predict more than 80% of oral cancer cases. These preliminary findings indicate that three species of bacteria may be incidentally or causally linked with OSCC, and if so detection of these species could be used as a simple, rapid and non-invasive saliva-test to diagnose oral cancer.
Previous studies have reported that certain common oral bacteria are often found on or in oral cancer lesions. Though previous research has reported that the microbiota of OSCC lesions differs from that found on the soft tissues of cancer-free individuals, little is known about the salivary microbiota of oral cancer patients. Currently, studies are examining whether bacteria may be incidentally or causally associated with oral cancer and if so, whether these species may be used as markers for oral cancer.
In order to determine if the salivary microbiota in patients with OSCC would differ from that found in oral cancer-free individuals, Donna Mager and colleagues, from the Forsyth Institute and the Dana Farber Cancer Institute in Boston, United States, collected saliva samples from 45 individuals diagnosed with OSCC and 229 controls. A computer then matched a subset of 45 members of the control group for age, gender and smoking with the 45 OSCC subjects. The saliva samples were then individually analysed for their content of forty bacterial species using bacterial DNA probes.
Juliette Savin | alfa
A novel socio-ecological approach helps identifying suitable wolf habitats
17.02.2017 | Universität Zürich
New, ultra-flexible probes form reliable, scar-free integration with the brain
16.02.2017 | University of Texas at Austin
In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".
Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
20.02.2017 | Materials Sciences
20.02.2017 | Health and Medicine
20.02.2017 | Health and Medicine