Study marks first step in decoding gene regulatory logic
Investigators from the University California, San Diego (UCSD) Branch of the Ludwig Institute for Cancer Research (LICR) and NimbleGen Systems have developed an efficient method to identify thousands of regulatory sequences in the human genome, according to a study published today in Nature.
Genes are defined by their ability to generate a functional product. Thus the promoter - a DNA sequence that controls when and where a gene product is generated - is the critical element that distinguishes a gene from junk DNA. Using a set of NimbleGens DNA microarrays that represent the entire human genome, the team was able to track critical proteins binding to each genes promoter to identify 10,567 active promoters, 6 091 of which were previously unknown.
Sarah L. White, Ph.D. | EurekAlert!
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