A 3-D model of a DNA nanostructure. In figure A, three long cylinders of individual helices (black) contain regularly spaced intervals of aptamers (red) which can bind to a protein. In figure (B), a thrombin protein (green circle) binds to the DNA aptamer structure.
An atomic force microscopy image of the thrombin/DNA complex. The DNA appears as two long threads in the center of the image, with the brighter spots corresponding to thrombin proteins attached to the DNA.
In the fifty-year history since the structure of DNA was first revealed, what was once a Nobel prize- winning research discovery has become an omnipresent cultural icon co-opted for promoting everything from fragrances to musical acts. Now, the familiar DNA double helix is serving as a microscopic trellis in order to further advances in nanotechnology aimed at improving human health.
Hao Yan, a researcher at the Biodesign Institute at Arizona State University and an assistant professor in ASU’s Department of Chemistry and Biochemistry, recently created unique arrays of proteins tethered onto self-assembled DNA nanostructures.
While other efforts in recent years have focused on learning how to build DNA-based nanostructures, Yan’s work is novel because it makes it feasible to attach any desired biomolecule onto DNA nanostructures. Such work is an important step and can serve as a future foundation for biocatalytic networks, drug discovery or ultrasensitive detection systems.
One step closer to reality
20.04.2018 | Max-Planck-Institut für Entwicklungsbiologie
The dark side of cichlid fish: from cannibal to caregiver
20.04.2018 | Veterinärmedizinische Universität Wien
University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.
Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.
Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.
The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...
Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.
Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...
In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...
13.04.2018 | Event News
12.04.2018 | Event News
09.04.2018 | Event News
20.04.2018 | Physics and Astronomy
20.04.2018 | Interdisciplinary Research
20.04.2018 | Physics and Astronomy