Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Anti-AIDS Drug Becomes Ten Times Less Toxic

17.06.2005


Outstanding antiviral action of multiple antibiotics remains unclaimed due to high drug toxicity. Russian physicians are trying to get nontoxic drug dosage form and have achieved success as regards to anit-AIDS antibiotic – Heliomycinum. Their effort has been funded by the International Science and Technology Center.



Specialists of the Lomonosov Moscow State Academy of Fine Applied Chemistry and Ivanovsky Scientific Research Institute of Virology (Russian Academy of Medical Sciences) have found the way to reduce by ten times toxicity of anit-AIDS antibiotic Heliomycinum (Resistomycinum). To this end, antibiotic was enclosed into an adipose (lipidic) bubble - liposome.

Utilization of liposomes as a carrier of drugs is increasingly attracts attention of researchers. Liposomes are non-toxic and get fully decomposed in the organism. As lipids’ disintegration occurs gradually, the drug enclosed in liposome is also released in small doses, thus allowing to create drugs with durable action and to reduce their toxicity.


Heliomycinum is one of the drugs whose toxicity the researchers are eager to reduce. This antibiotic blocks the action of several specific enzymes of human immunodeficiency virus, therefore, it has been considered a promising antiviral drug for a long time. However, Heliomycinum has not been widely accepted in medicine due to very poor solubility in water and high toxicity. Heliomycinum inclusion into liposomes would improve the drug quality and allow to create its injection form of low toxicity.

To obtain a liposomic drug, the researchers added the Heliomycinum solution in the chloroform and methanol mixture to the lipidic film. Samples were frozen in liquid nitrogen and stirred up at room temperature. The freezing/thawing cycle was repeated for five more times. As a result, antibiotic embedded into the lipidic film. Then, the mixture was forced through the filters with small interstices to separate non-bound Heliomycinum, and the medicinal mixture itself was smashed to small bubbles containing known concentration of antibiotic. The researchers sorted out such lipid composition that up to 97 percent of Heliomycinum is included into liposomes. Having hidden Heliomycinum into liposomes, the researchers succeeded to dissolve it in physiological solution, which is important for pharmaceutical purposes.

The liposome drug toxicity was tried on the culture of embryonic fibroblasts. Heliomycinum in aqueous solution destroyed every single cell already within 24 hours, and toxicity of liposomic form turned out to be ten times lower. Antiviral activity of liposomic Heliomycinum was tried on the culture of fibroblasts which were infected by cytomegalovirus. This human virus does not cause diseases and ideally fits for model experiments. A new drug has turned out to be active against virus, the drug being applied in such concentration that it is non-toxic for cells.

Sergey Komarov | alfa
Further information:
http://www.informnauka.ru

More articles from Life Sciences:

nachricht Polymers Based on Boron?
18.01.2018 | Julius-Maximilians-Universität Würzburg

nachricht Bioengineered soft microfibers improve T-cell production
18.01.2018 | Columbia University School of Engineering and Applied Science

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

Im Focus: A thermometer for the oceans

Measurement of noble gases in Antarctic ice cores

The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Polymers Based on Boron?

18.01.2018 | Life Sciences

Bioengineered soft microfibers improve T-cell production

18.01.2018 | Life Sciences

World’s oldest known oxygen oasis discovered

18.01.2018 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>