Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Biological warfare, mad cow disease on UH student’s hit list


Mrinal Shah develops technology to construct biosensors more quickly

A University of Houston student has made an award-winning breakthrough in biosensors that could help bioterrorism researchers in their ability to quickly and accurately detect toxic biological agents.

Mrinal Shah, a doctoral student in chemical engineering at UH, has developed new methods in the use of biosensors that could provide one of the first steps in developing a protein-based biosensor that would help the government in safeguarding the nation.

Working under the direction of Peter Vekilov, a world-renowned expert in the field of nucleation and a chemical engineering professor at the UH Cullen College of Engineering, Shah employs liquid-liquid phase separation – a technique that is similar to the concept behind how oil and water separate. His research makes use of the proteins needed in biosensors and accurately controls the nucleation of those proteins.

"The development of a successful biosensing chip has potential uses that are manifold and urgently needed with several applications that are immediately significant," Shah said. "If there is biological warfare somewhere, and you put this chip into that environment, you would know exactly what is in that environment, and safety precautions could be taken. That’s the ultimate achievement that every scientist working in protein chips dreams about."

Biosensing chips are already in use for studies such as the quality control of water and checking glucose levels. Shah’s involvement in the biosensing application began with his initial interest in protein nucleation that occurs with diseases such as Parkinson’s, sickle cell anemia and Alzheimer’s. While his methods may prove useful in the early detection of these diseases, Shah said he is not searching for any cures. He said that what basically happens is the protein is normal inside the body, but then suddenly something happens for it to just start nucleating. The protein misfolds, denatures and begins to aggregate together forming into the disease.

"We’re not finding cures ourselves, but we are finding the mechanisms that follow the formations of these fibers," Shah said. "Once we know the mechanism, then we also can know by what methods to reduce the rate of its formation. The physics behind the mechanisms is much more interesting to us."

Shah says there are a number of other applications for the chip, as well, including combating mad cow disease and anthrax.

While working on the initial part of his project – studying the kinetics and the thermodynamics involved to better understand what mechanisms govern the phase separation of nanoscale droplets of protein solution – Shah came up with the idea that could lead to a new potential way of making biosensors that would be fast and easy. He found that control over nucleation is essential to the creation of biosensors.

"It was a difficult project, because we were hoping that one of two approaches would work, and neither of them did," Vekilov said. "We tried electrophoresis and dielectrophoresis and neither worked. But Mrinal kept working, kept trying new things and finally developed his own method. What we discovered is that the solution has a time-dependent, non-uniform electric field, and this is what causes the nucleation."

"The next step will be to tag the protein molecule onto the micro-area electrode," Shah said. "That will be a challenge, but we already have several promising strategies in mind."

Since winning second place at last year’s Keck Annual Research Conference, Shah has been able to replicate his results, using a more widely used biosensing protein – horseradish peroxidase. The W.M. Keck Center for Computational and Structural Biology is designed to unite modern biological, physical and computational sciences in addressing problems in biology and biomedicine. Its six member institutions include UH, Rice University, Baylor College of Medicine, The University of Texas Health Science Center at Houston, The University of Texas Medical Branch at Galveston and The University of Texas M.D. Anderson Cancer Center.

Lisa Merkl | EurekAlert!
Further information:

More articles from Life Sciences:

nachricht International team discovers novel Alzheimer's disease risk gene among Icelanders
24.10.2016 | Baylor College of Medicine

nachricht New bacteria groups, and stunning diversity, discovered underground
24.10.2016 | DOE/Lawrence Berkeley National Laboratory

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

New method increases energy density in lithium batteries

24.10.2016 | Power and Electrical Engineering

International team discovers novel Alzheimer's disease risk gene among Icelanders

24.10.2016 | Life Sciences

New bacteria groups, and stunning diversity, discovered underground

24.10.2016 | Life Sciences

More VideoLinks >>>