An international research team has discovered a new target molecule, Fbw7, for developing drugs with the potential to complement or replace statins in the treatment of cardiovascular diseases. The findings are being published in the new issue of the scientific journal Cell Metabolism.
Cholesterol is a fat-like substance that is needed for the formation of our cells and for the production of hormones. The amount needed can be provided by the body itself, but our eating habits often lead to too much cholesterol. The surplus is stored in the walls of our vessels, thereby increasing the risk of cardiovascular disorders, the most common cause of death in the Western world. What‚s more, individuals with cardiovascular diseases run a greater risk of being overweight and contracting diabetes.
The protein SREBP regulates the genes that control the amount of cholesterol and other fats in cells. SREBP‚s ability to regulate the new production, metabolism, and uptake of cholesterol from the blood is extremely important in the liver, where huge quantities of cholesterol are absorbed and rendered harmless. SREBP is therefore a suitable target molecule for the development of new drugs for cardiovascular diseases, overweight, and diabetes.
Anneli Waara | alfa
22.02.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau
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