Researchers have produced the strongest evidence yet that mitochondria — the organelles that generate energy to power the cell — also monitor oxygen concentration in the cell. If oxygen slips below a critical threshold, the mitochondrial “sensor” triggers protective responses to promote survival.
Understanding how the cell senses and protects itself against hypoxia (low oxygen) has both important basic and clinical implications for biology and medicine, said one of the study’s senior authors, M. Celeste Simon, a Howard Hughes Medical Institute investigator at the University of Pennsylvania. “Oxygen is absolutely essential for life, so the biological mechanisms underlying response to low oxygen are central to the cell,” she said. “For example, during early development, the embryo exists in a naturally hypoxic environment until it is connected to the maternal cardiovascular system.
“In the adult, changes in oxygen levels occur during inflammation and atherosclerosis; and even transient oxygen starvation can have a profound impact on the brain,” said Simon. “For example, the well-known case of the late Terry Schiavo, in which a cardiac episode reduced her to a vegetative state, was the result of only brief oxygen starvation.”
Jim Keeley | EurekAlert!
Foster tadpoles trigger parental instinct in poison frogs
20.09.2017 | Veterinärmedizinische Universität Wien
MicroRNA helps cancer evade immune system
19.09.2017 | Salk Institute
Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!
When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...
For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.
Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...
MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.
MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems...
Pathogenic bacteria are becoming resistant to common antibiotics to an ever increasing degree. One of the most difficult germs is Pseudomonas aeruginosa, a...
Scientists from the MPI for Chemical Energy Conversion report in the first issue of the new journal JOULE.
Cell Press has just released the first issue of Joule, a new journal dedicated to sustainable energy research. In this issue James Birrell, Olaf Rüdiger,...
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