Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New finding in studying dopamine transporter

08.06.2005


Confirming findings in a previous study, Yale researchers observed an altered availability of the dopamine transporter in healthy persons with a genetic variation linked to substance abuse and attention deficit hyperactivity disorder (ADHD).


"Healthy people who carry a particular variant of the dopamine transporter gene, the nine repeat allele, have significantly higher levels of dopamine transporter in the brain," said the lead author, Christopher van Dyck, M.D., associate professor of psychiatry and neurobiology and director of the Alzheimer’s Disease Research Unit and the Cognitive Disorders Clinic in the Department of Psychiatry.

The new study included 96 healthy European Americans--54 men and 42 women--who underwent a clinical examination to exclude any neurological or psychiatric disease, alcohol abuse or substance abuse. The levels of dopamine transporter availability were measured using SPECT imaging, and the dopamine transporter genotypes were determined by co-author Joel Gelernter, M.D.

"We are not yet sure if the effects of the variant on transporter levels in our healthy subjects can be generalized to neuropsychiatric disorders," van Dyck said. "If they can be, our results may be relevant for substance abuse, tobacco smoking, and ADHD. "The results suggest that the mechanism of association of this gene with several disorders could be altered levels of central dopamine transporter protein, influencing concentrations of extracellular dopamine."



This study replicated and expanded on a preliminary report by Leslie Jacobsen, M.D., and colleagues at Yale, although other studies of the effects of this variation on the availability of the dopamine transporter have yielded contradictory results.

In addition to Jacobsen and Gelernter, co-authors included Robert Malison, M.D., John Seibyl, M.D., Julie Staley, Marc Laruelle, M.D., Ronald Baldwin, and Robert Innis, M.D. The study was supported by grants and funds from the American Federation for Aging Research; Rose and Philip Hoffer; the Department of Veterans Affairs; the National Institute of Mental Health, and the National Institute on Drug Abuse.

Jacqueline Weaver | EurekAlert!
Further information:
http://www.yale.edu

More articles from Life Sciences:

nachricht A novel socio-ecological approach helps identifying suitable wolf habitats
17.02.2017 | Universität Zürich

nachricht New, ultra-flexible probes form reliable, scar-free integration with the brain
16.02.2017 | University of Texas at Austin

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Biocompatible 3-D tracking system has potential to improve robot-assisted surgery

17.02.2017 | Medical Engineering

Real-time MRI analysis powered by supercomputers

17.02.2017 | Medical Engineering

Antibiotic effective against drug-resistant bacteria in pediatric skin infections

17.02.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>