Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Removing the spleen may help fight leukemia, mouse model suggests

02.06.2005


Early surgical removal of the spleen combined with antiangiogenic cancer therapy may halt the progression of leukemia, according to scientists at Sunnybrook and Women’s College Health Sciences Centre.

The research, published today in Blood, is the first to show the combination of two factors secreted from the environment of the spleen is important in the promotion of leukemia.

Dr. Yaacov Ben-David, a Senior Scientist in Molecular and Cellular Biology at the Sunnybrook & Women’s Research Institute who is the lead investigator in the study and colleagues, including Dr. Yuval Shaked, a post-doctoral fellow, discovered that the spleen of diseased mice provides a supportive environment for cancer cells. The spleen secretes various factors, among them MCP and VEGF, which relate to the immune system and promote formation of new blood vessels. Secretions of these factors cause leukemic cells in the spleen to multiply. In this study, Dr. Ben-David’s team showed that these factors might contribute to the progression of breast and other types of cancer.



"For the first time we have been able to provide evidence that the environment around the spleen may play a critical role for patients with leukemia and possibly other types of cancers," says Dr. Ben-David who is also an Associate Professor of Medical Biophysics at the University of Toronto. "When combined with antiangiogenic cancer therapies that work by halting the development of new blood vessels that feed tumor growth, we found that mice experienced prolonged survival."

In the human body, the spleen is located in the upper left side of the abdomen, behind the stomach. Its functions are to filter blood, remove bacteria and make and store blood. Since it is involved in so many bodily functions, it is vulnerable to a wide range of disorders. Any condition that infects the spleen, such as leukemia, can place great strain on the organ and cause it to enlarge. The human body can adapt well to life without this organ, so surgically removing a diseased or damaged spleen is worth further investigation.

Researchers suggest that early surgical intervention by removing the spleen and suppressing the related factors might be considered as a treatment model for human hematological malignancies, cancers of the body’s blood-forming and immune systems. Since the research was conducted on mice and does not apply to humans, further research and clinical trials are required before this is practice will be considered as a treatment option in the clinic.

Jennifer White | EurekAlert!
Further information:
http://www.sw.ca
http://www.utoronto.ca

More articles from Life Sciences:

nachricht Rutgers scientists discover 'Legos of life'
23.01.2018 | Rutgers University

nachricht Researchers identify a protein that keeps metastatic breast cancer cells dormant
23.01.2018 | Institute for Research in Biomedicine (IRB Barcelona)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Optical Nanoscope Allows Imaging of Quantum Dots

Physicists have developed a technique based on optical microscopy that can be used to create images of atoms on the nanoscale. In particular, the new method allows the imaging of quantum dots in a semiconductor chip. Together with colleagues from the University of Bochum, scientists from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute reported the findings in the journal Nature Photonics.

Microscopes allow us to see structures that are otherwise invisible to the human eye. However, conventional optical microscopes cannot be used to image...

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Rutgers scientists discover 'Legos of life'

23.01.2018 | Life Sciences

Seabed mining could destroy ecosystems

23.01.2018 | Earth Sciences

Transportable laser

23.01.2018 | Physics and Astronomy

VideoLinks Science & Research
Overview of more VideoLinks >>>