Scientists have for the first time mapped multiple complex biological interactions in a yeast cell in a simple graphical form, enhancing our understanding of how the networks of interaction by which components of a cell influence one another. New research published in the Open Access journal Journal of Biology shows that such maps can also reveal cryptic interactions and enable accurate predictions about interactions that havent been observed experimentally.
A living cell contains thousands of proteins, genes and macromolecules, enmeshed in complex webs of relationships involving direct or indirect contact. At the simplest level, some recurring patterns of interconnections occur more frequently than expected in randomized networks, and these are called network motifs. Lan Zhang from Harvard Medical School, USA, and colleagues found that the concept of network themes – recurring complex patterns that encompass multiple occurrences of network motifs – allows the building of thematic maps of interactions between macromolecules that can be tied to biological phenomena and may help represent more fundamental network design principles than do simple motifs.
Zhang et al. integrated five different types of biological relationships found in the yeast Saccharomyces cerevisae: protein-protein interactions, genetic interactions, transcriptional regulation, sequence homology and expression correlation. The authors are the first to integrate so many types of data to search for network motifs. The authors conclude that most network motifs found in the integrated S. cerevisae network can be understood in terms of just a few network themes, associated with specific biological phenomena.
Juliette Savin | EurekAlert!
Multi-institutional collaboration uncovers how molecular machines assemble
02.12.2016 | Salk Institute
Fertilized egg cells trigger and monitor loss of sperm’s epigenetic memory
02.12.2016 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water
In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...
The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.
Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...
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