Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

World record in mass spectrometry

30.05.2005


Scientists at ETH Zurich have set a world record in mass spectrometry by observing the largest ever mass-to-charge ratio of over 1 Mio Dalton (MDa) using a special mass spectrometer. The researchers in the team of Prof. Renato Zenobi had to overcome two obstacles, the intact vaporization and ionization of the sample, as well as the detection of the very large ions. Modern soft ionization methods allow giant molecules such as proteins or DNA to be brought into the gas phase. The ETH researchers employed desorption and ionization using a pulsed UV laser.



For mass separation, they used a time-of-flight mass spectrometer, which separates ions of different mass-to-charge ratio by their drift time through an evacuated fligh tube. The largest ions take the longest time, and are difficult or impossible to detect with conventional detectors, due to their small drift velocity. One possibility would be to produce multiply charged ions and detect them in a more accessible mass-to-charge ratio range. The ETH researchers chose a more direct and elegant way, by carrying out their measurements on an instrument developed by Comet AG of Switzerland equipped with a superconducting tunnel junction detector. In this way, simple and directly interpretable mass spectra were obtained from immunoglobuline M (ca. 1 MDa) and from von Willebrand factor, a group of proteins that play an important role in coagulation of blood (signals at 0.5, 1, 1.5 and 2 MDa).

Renato Zenobi | alfa
Further information:
http://www.ethz.ch/news/ethupdate/2005/050524_2/index_EN

More articles from Life Sciences:

nachricht Synthetic nanoparticles achieve the complexity of protein molecules
24.01.2017 | Carnegie Mellon University

nachricht Immune Defense Without Collateral Damage
24.01.2017 | Universität Basel

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Quantum optical sensor for the first time tested in space – with a laser system from Berlin

For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.

According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Arctic melt ponds form when meltwater clogs ice pores

24.01.2017 | Earth Sciences

Synthetic nanoparticles achieve the complexity of protein molecules

24.01.2017 | Life Sciences

PPPL physicist uncovers clues to mechanism behind magnetic reconnection

24.01.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>