Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

More than ’SNARE’ needed for proper synapse

20.05.2005


A protein identified by researchers at Baylor College of Medicine appears to play a major role in the release of neurotransmitters and therefore communication between nerve cells.



In a report that is the cover article in the current issue of the journal Cell, Dr. Hugo Bellen, BCM professor of molecular and human genetics and a Howard Hughes Medical Institute investigator, and his colleague Dr. P. Robin Hiesinger demonstrate that a protein called Vha100-1, a member of the pore-forming V0 complex, plays a crucial role in the transmission of a message from one nerve cell to another.

The fusion of vesicles that connect the neurotransmitter to the membrane of the cell is a critical step in this transfer. Whether neurotransmitter is released through a protein pore has been a matter of debate for many years. Previously, it was believed that SNARE (soluble N-ethylmaleimidesensitive factor attachment protein receptor) proteins were all that was needed for this fusion.


In this paper, Bellen and his colleagues argue that Vha100-1 is another component that together with the SNARES are critical for the fusion and the release of a neurotransmitter. They identified this protein through a special screening procedure in fruit flies that allows them to identify functional defects in the fly eye.

They found that the mutant fly eyes that lacked Vha100-1 were blind, indicating that information was not being communicated, said Bellen. Using molecular genetics, electrophysiology, biochemistry, electron microscopy and yeast trans-species experiments, they determined that Vha100-1 was involved in membrane fusion and played a critical role in the release of a neurotransmitter after the action of the SNARE proteins.

Others who participated in the research include Drs. Amir Fayyazuddin, Sunil Q. Mehta, Tanja Rosenmund, Karen L. Schulze, Patrik Verstreken, Yu Cao, Yi Zhou and Jeannette Kunz.

Ross Tomlin | EurekAlert!
Further information:
http://www.bcm.tmc.edu

More articles from Life Sciences:

nachricht A Map of the Cell’s Power Station
18.08.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau

nachricht On the way to developing a new active ingredient against chronic infections
18.08.2017 | Deutsches Zentrum für Infektionsforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

New gene catalog of ocean microbiome reveals surprises

18.08.2017 | Life Sciences

Astrophysicists explain the mysterious behavior of cosmic rays

18.08.2017 | Physics and Astronomy

AI implications: Engineer's model lays groundwork for machine-learning device

18.08.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>