A gene commonly mutated in Crohn’s disease sufferers is responsible for allowing the body’s immune system to ‘chat’ to microbes in the gut. Researchers at Hammersmith Hospitals NHS Trust and Imperial College London who have uncovered the role of this gene say that it will now be possible to develop better tests for this debilitating disease, and will help researchers to uncover the genetic basis of Crohn’s and similar inflammatory bowel diseases.
Writing in the journal The Lancet tomorrow (21 May), the Hammersmith researchers describe the effect that mutations in the gene, known as NOD2/CARD15, has on the release of immune system molecules in the gut. Normally, the gene produces a protein that is involved in recognising bacteria in the gut. This recognition prevents the initiation of an early immune response, which subsequently leads to the lining of the gut becoming inflamed. In around a quarter of Crohn’s disease sufferers, mutations in the NOD2/CARD15 gene prevent this communication from taking place.
“The NOD2/CARD15 system was the first genetic defect found to be associated with Crohns disease, but until now we haven’t been able to understand exactly why this caused the disease,” comments study leader Dr David van Heel, gastroenterologist at Hammersmith Hospital and Imperial College London. “Our studies suggest that this defect does not allow the immune system to work properly in the very earliest stages of mounting an immune response."
Simon Wilde | alfa
Water forms 'spine of hydration' around DNA, group finds
26.05.2017 | Cornell University
How herpesviruses win the footrace against the immune system
26.05.2017 | Helmholtz-Zentrum für Infektionsforschung
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy