Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Gene mutation in Crohn’s disease stops body-bug chat

20.05.2005


A gene commonly mutated in Crohn’s disease sufferers is responsible for allowing the body’s immune system to ‘chat’ to microbes in the gut. Researchers at Hammersmith Hospitals NHS Trust and Imperial College London who have uncovered the role of this gene say that it will now be possible to develop better tests for this debilitating disease, and will help researchers to uncover the genetic basis of Crohn’s and similar inflammatory bowel diseases.



Writing in the journal The Lancet tomorrow (21 May), the Hammersmith researchers describe the effect that mutations in the gene, known as NOD2/CARD15, has on the release of immune system molecules in the gut. Normally, the gene produces a protein that is involved in recognising bacteria in the gut. This recognition prevents the initiation of an early immune response, which subsequently leads to the lining of the gut becoming inflamed. In around a quarter of Crohn’s disease sufferers, mutations in the NOD2/CARD15 gene prevent this communication from taking place.

“The NOD2/CARD15 system was the first genetic defect found to be associated with Crohns disease, but until now we haven’t been able to understand exactly why this caused the disease,” comments study leader Dr David van Heel, gastroenterologist at Hammersmith Hospital and Imperial College London. “Our studies suggest that this defect does not allow the immune system to work properly in the very earliest stages of mounting an immune response."


“The body normally senses microbes present in the gut that are essential in maintaining normal gut function, and there is regular cross-talk between the gut lining and the microbes that they contain. This functional defect probably disrupts this natural process.”

“We think that this new finding provides a basis for new tests for Crohn’s disease, with implications for both research and future treatments,” adds Dr van Heel, gastroenterologist at Hammersmith Hospital and Imperial College, who led the study.

Crohn’s disease affects between 30,000 and 60,000 people in the UK, with between 3,000 and 6,000 new cases diagnosed each year. The number of people with Crohn’s disease has been rising steadily, particularly among young people.

It can affect anywhere from the mouth to the anus but most commonly affects the small intestine and/or colon. It causes inflammation, deep ulcers and scarring to the wall of the intestine and often occurs in patches. The main symptoms are pain in the abdomen, urgent diarrhoea, general tiredness and loss of weight. Crohn’s is sometimes associated with other inflammatory conditions affecting the joints, skin and eyes.

"These results, although some way from providing clinical treatment, are extremely encouraging," comments Professor Subrata Ghosh, medical advisor to NACC - the National Association for Colitis and Crohn’s Disease, and one of the co-authors of the study. "In addition to helping patients with this faulty gene, we may find that patients without this particular genetic defect have similar disruptions to other parts of the NOD2/CARD15 system. Our hope is that this will lead to the identification of further genetic defects, and ultimately to new treatment strategies."

Simon Wilde | alfa
Further information:
http://www.hhnt.nhs.uk

More articles from Life Sciences:

nachricht Polymers Based on Boron?
18.01.2018 | Julius-Maximilians-Universität Würzburg

nachricht Bioengineered soft microfibers improve T-cell production
18.01.2018 | Columbia University School of Engineering and Applied Science

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

Im Focus: A thermometer for the oceans

Measurement of noble gases in Antarctic ice cores

The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Polymers Based on Boron?

18.01.2018 | Life Sciences

Bioengineered soft microfibers improve T-cell production

18.01.2018 | Life Sciences

World’s oldest known oxygen oasis discovered

18.01.2018 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>