Researchers have located a gene dubbed dead end that when mutated or lost, causes testicular tumors in mice. They say their study, published in the online journal Nature, on May 18, 2005 will likely offer future insights into the genetic causes of the disease in humans because the cancer originates from the same cell type, the primordial germ cell, in both mice and men.
If that notion is validated through further research, the finding could lead to a way to either screen for the human disease or treat it, say the researchers, who represent The University of Texas M. D. Anderson Cancer Center, Case Western Reserve University, Duke University Medical Center, the National Cancer Institute and the Lawrence Berkeley National Laboratory.
"One can envision that this gene or others in its pathway could possibly be used for screening or therapeutic purposes in young males predisposed to develop testicular cancer or those who have a family history of this disease," says the lead investigator, Angabin Matin, Ph.D., an assistant professor in the Department of Molecular Genetics at M. D. Anderson. "This will of course require further research regarding the function of this gene in human cancers."
Nancy Jensen | EurekAlert!
One step closer to reality
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University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.
Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.
Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.
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Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.
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In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...
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20.04.2018 | Physics and Astronomy