Findings demonstrate that abnormal expression of the BCL6 gene causes lymphoma
Researchers at Columbia University Medical Center have created the first mouse model that develops a lymphoma the same way that humans do. This advancement has the potential to significantly speed the development of new, improved therapies for diffuse large B cell lymphoma (DLBCL), the most common type of human B cell lymphoma. Human B cell lymphomas cause 85 percent of non-Hodgkins lymphomas, the sixth leading cause of cancer deaths in the United States.
The findings also confirm that a mutation in BCL6, the gene most frequently altered in this type of lymphoma, is the first step in its development, though other subsequent mutations also occur. In the study, mice with a mutant form of this gene spontaneously developed this lymphoma.
Elizabeth Streich | EurekAlert!
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