Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cancer exploits the body’s wound-healing process

06.05.2005


Scientists have known for the last decade that a link exists between wound healing and cancer. For instance, in a 1994 experiment at the Lawrence Berkeley National Laboratory, chickens infected with a cancer virus developed tumors in areas of their body that had undergone wounding or scarring, while no tumors developed in infected areas that had not suffered wounding. However, the biological mechanism for this process hasn’t been clear.



Now, through studying muscle tissue in breast cancer, scientists in the lab of Whitehead Institute Member Robert Weinberg have discovered the process by which tumors hijack normal wound-healing processes and use them for their own purposes.

Reported in the May 6 issue of the journal Cell, the research began when Akira Orimo, a postdoctoral scientist in Weinberg’s lab, investigated the nature of stromal cells found in breast cancer tumors. Stromal cells form the connective tissue in a mammal’s organs and glands. They also form the connective tissue inside a tumor. Tumors are composed mostly of cancer cells and stromal cells, and researchers have wondered if the stromal cells in tumors function any differently than they do in normal tissues. Do they simply hold the tumor together the same way they hold a pancreas or a liver together, or do they actively work with the cancer cells in promoting the tumor’s growth? "It turns out the cancer cells are not acting alone," says Weinberg, who is also a Professor of Biology at MIT. "These stromal cells play an important role in helping these cells, and therefore tumors, to grow."


Orimo found that a particular protein produced by the stromal cells and recruited into human breast cancers, called SDF-1, is a key player in helping tumors grow. SDF-1 interacts with a class of cells called endothelial precursor cells. Found primarily in the blood, these cells travel throughout the body and help aid wounded tissue by enabling new blood vessels to form, a process called angiogenesis. They are an integral part of the body’s ability to heal itself.

The stromal cells in the breast cancer tumor produce SDF-1, which in turn persuades these endothelial precursor cells to enter the tumor. Once they do, they help the tumor to form its own robust network of blood vessels, weaving a circulatory system throughout the tumor mass. The tumor can now access the nutrients present in the host’s circulating blood and can then grow unchecked. "Essentially, these stromal cells opportunistically exploit the normal wound healing process to benefit the tumor," says Weinberg.

In recent years, scientists have focused on angiogenesis as a target for therapeutics, with some success. "These findings are one part of the larger angiogenesis picture," says Weinberg. "They lend precision and specificity to that overall scheme."

Orimo now plans to further investigate this process by disturbing the interactions between the stromal cells and the cancer cells, work that may yield new therapeutic insights.

David Cameron | EurekAlert!
Further information:
http://www.wi.mit.edu

More articles from Life Sciences:

nachricht New risk factors for anxiety disorders
24.02.2017 | Julius-Maximilians-Universität Würzburg

nachricht Stingless bees have their nests protected by soldiers
24.02.2017 | Johannes Gutenberg-Universität Mainz

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>