Scientists have known for the last decade that a link exists between wound healing and cancer. For instance, in a 1994 experiment at the Lawrence Berkeley National Laboratory, chickens infected with a cancer virus developed tumors in areas of their body that had undergone wounding or scarring, while no tumors developed in infected areas that had not suffered wounding. However, the biological mechanism for this process hasnt been clear.
Now, through studying muscle tissue in breast cancer, scientists in the lab of Whitehead Institute Member Robert Weinberg have discovered the process by which tumors hijack normal wound-healing processes and use them for their own purposes.
Reported in the May 6 issue of the journal Cell, the research began when Akira Orimo, a postdoctoral scientist in Weinbergs lab, investigated the nature of stromal cells found in breast cancer tumors. Stromal cells form the connective tissue in a mammals organs and glands. They also form the connective tissue inside a tumor. Tumors are composed mostly of cancer cells and stromal cells, and researchers have wondered if the stromal cells in tumors function any differently than they do in normal tissues. Do they simply hold the tumor together the same way they hold a pancreas or a liver together, or do they actively work with the cancer cells in promoting the tumors growth? "It turns out the cancer cells are not acting alone," says Weinberg, who is also a Professor of Biology at MIT. "These stromal cells play an important role in helping these cells, and therefore tumors, to grow."
David Cameron | EurekAlert!
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23.10.2017 | Penn State
Key discoveries offer significant hope of reversing antibiotic resistance
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University of Maryland researchers contribute to historic detection of gravitational waves and light created by event
On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....
Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...
Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...
Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.
It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...
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