Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Jefferson Scientists Create Plant Factories Churning Out Antibodies Against Tumor Cells

04.05.2005


Scientists at Jefferson Medical College are using tobacco plants to produce monoclonal antibodies – tiny guided protein missiles – that can target and hunt down cancer cells. The plants promise to provide a cheaper, faster method of producing anticancer antibodies, raising hopes that the technology can one day be used in humans.

Scientists, led by Hilary Koprowski, M.D., professor of microbiology and immunology and director of the Biotechnology Foundation Laboratories and the Center for Neurovirology at Jefferson Medical College of Thomas Jefferson University in Philadelphia and Kisung Ko, Ph.D., an instructor in the Department of Microbiology and Immunology at Jefferson Medical College, inserted DNA coding for an antibody against colorectal cancer into tobacco plants. The plants, in turn, become factories churning out antibody.
The report appears online this week in the Proceedings of the National Academy of Sciences.


Standard mouse-made monoclonals recognize a particular type of protein antigen on human colorectal cancer cells and have been used in treating metastatic disease and in preventing recurrence in certain high-risk patients. But the technology to produce large amounts of antibody is expensive, and researchers would like to find alternatives. Dr. Koprowski, Dr. Ko and their co-workers had previously shown that tobacco plant-made monoclonal antibodies could neutralize rabies virus and prevent disease in infected mice. They wanted to find out if plant-made antibodies could be effective for cancer immunotherapy.

They first showed that plant-made monoclonal antibody purified from tobacco leaves could recognize, or bind to, human colorectal cancer cells. Next, they grafted human colorectal cancer cells onto the backs of nude mice – mice stripped of their immune systems, and subsequently injected the animals with the plant-derived antibodies. Then they watched for tumor growth for as many as 40 days.

The researchers found that tumor growth was inhibited in a similar manner to that of mammalian-made monoclonal antibodies, Dr. Ko says. “These results indicate that plant biotechnology can be a useful alternative to produce monoclonal antibodies,” he says. “The antibody produced in tobacco is as good as the antibody produced in animal cells,” says Dr. Koprowski, noting that tobacco-derived antibody should be safer and less expensive to produce.

The Jefferson scientists are seeking industry partners to begin mass production of the antibody. The next step in the work, Dr. Koprowski notes, would be to conduct a phase 1 clinical trial of the monoclonal antibody in colorectal cancer patients. In the meantime, they are studying the effectiveness of monoclonal antibodies against other types of cancer, including breast tumor and lung tumor cells, in laboratory animals.

Steve Benowitz | EurekAlert!
Further information:
http://www.jefferson.edu

More articles from Life Sciences:

nachricht CWRU researchers find a chemical solution to shrink digital data storage
22.06.2017 | Case Western Reserve University

nachricht Warming temperatures threaten sea turtles
22.06.2017 | Swansea University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

Im Focus: Optoelectronic Inline Measurement – Accurate to the Nanometer

Germany counts high-precision manufacturing processes among its advantages as a location. It’s not just the aerospace and automotive industries that require almost waste-free, high-precision manufacturing to provide an efficient way of testing the shape and orientation tolerances of products. Since current inline measurement technology not yet provides the required accuracy, the Fraunhofer Institute for Laser Technology ILT is collaborating with four renowned industry partners in the INSPIRE project to develop inline sensors with a new accuracy class. Funded by the German Federal Ministry of Education and Research (BMBF), the project is scheduled to run until the end of 2019.

New Manufacturing Technologies for New Products

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Innovative LED High Power Light Source for UV

22.06.2017 | Physics and Astronomy

Mathematical confirmation: Rewiring financial networks reduces systemic risk

22.06.2017 | Business and Finance

Spin liquids − back to the roots

22.06.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>