ATM and ATR are key effectors of the cellular response to DNA damage, instructing a damaged cell to halt cell cycle progression and either initiate DNA repair processes or programmed cell death. While much research has focused on the identification of moleculaes that help transduce these signals throughout the cell, in their current paper, Dr. Lawrence Donehower and colleagues address the issue of how a cell returns to normal after DNA damage is successfully repaired.
Dr. Donehower and colleagues show that the phosphatase PPM1D effectively curtails the DNA damage checkpoint response by dephosphorylating the ATM/ATR targets, Chk1 and p53 – enabling the cell to resume a homeostatic state. "From my point of view, the most interesting thing about this study is a new insight on p53 regulation…those tumors that show amplified and overexpressed PPM1D may be analogous to those tumors with amplified and overexpressed MDM2. In both tumor types, p53 may be functionally inactivated and this promotes tumorigenesis," explains Dr. Donehower.
Heather Cosel | EurekAlert!
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20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH
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20.01.2017 | DOE/Joint Genome Institute
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
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Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
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Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
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