RNA-guided RNA pseudouridylation in archaea
Pseudouridylation is one of the most abundant forms of post-transcriptional RNA modification in eukaryotes and archaea, and plays a key role in the generation and correct functioning of cellular RNAs. The modifications are made by a complex of proteins directed to target sites by integral non-coding guide RNAs.
Drs. Michael and Rebecca Terns and colleagues have effectively reconstituted the archaeal modification guide ribonucleoprotein complex that guides pseudouridylation in vitro in a site-specific manner. This study provides unprecedented insight into the organization and function of pseudouridylation guide RNPs, and Dr. Terns indicates that "this is only the beginning of the gold mine of new information that this system will yield about a complex that is also involved in rRNA processing and the function of telomerase in eukaryotes."
Heather Cosel | EurekAlert!
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For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
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For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.
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