In a paper in this months freely-available online global health journal PLoS Medicine Seung Kim and colleagues from Stanford University suggest that one way of producing insulin-secreting pancreatic islet cells for future possible treatment of type I diabetes is to look beyond immature pancreatic cells and embryonic stem cells to other early cell types. Kim and colleagues took cells derived from brain which usually mature into neural cells, and exposed them to a series of signals that are known to drive pancreatic islet development. They were able to produce clusters of insulin-producing cells that responded to glucose out of the body.
Insulin-producing neurospheres. (Photo: Seung Kim et al.)
When the cells were then transplanted into immunocompromised mice the cells could also be stimulated by glucose to produce human insulin. Future work will need to establish the long-term stability and safety of these cells and to work out how to scale up such a process to produce the much larger numbers of cells that would be needed for human treatment. However, the authors conclude that this technique "could serve as the basis for developing replacement islets from a wide range of human stem cells, including neural stem cells and ES cells."
Research team of the HAW Hamburg reanimated ancestral microbe from the depth of the earth
01.03.2017 | Hochschule für Angewandte Wissenschaften Hamburg
Researchers Imitate Molecular Crowding in Cells
01.03.2017 | Universität Basel
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded after a glide flight with an Airbus A320 in ditching on the Hudson River. All 155 people on board were saved.
On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded...
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
01.03.2017 | Health and Medicine
01.03.2017 | Physics and Astronomy
01.03.2017 | Life Sciences