The complexity of the brain and, more specifically, how nerve cells form billions of contacts when there are fewer than 30,000 human genes is still a scientific mystery.
A team headed by Drs. Robin Hiesinger and Hugo J. Bellen at Baylor College of Medicine in Houston have unraveled a piece of that puzzle by finding a gene that plays a key role in brain wiring. A report on their work appears today in the journal Neuron.
"We were surprised to find an exocyst mutant having such specific defects," said Bellen, professor of molecular and human genetics at BCM. "The cell biological basis of brain wiring is largely unknown. We are happy to have a new handle on an old problem."
Ross Tomlin | EurekAlert!
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