U of T researchers develop new chemical reaction
University of Toronto researchers have a developed a new chemical reaction that could greatly accelerate pharmaceutical production, while also cutting costs and toxic by-products.
The reaction, designed by chemistry Professor Mark Lautens and graduate student Eric Fang, simplifies the creation of the basic molecular framework found in many natural products and popular pharmaceuticals like some cholesterol-lowering drugs. Until now, synthesizing this framework - an indole - was inefficient, requiring six to 10 steps and often producing toxic by-products. "This new method only takes three steps and results in less waste," says Lautens, the NSERC-Merck Frosst Industrial Research Chair in New Medicinal Agents via Catalytic Reactions and AstraZeneca Professor of Organic Synthesis.
Prof. Mark Lautens | EurekAlert!
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