A study appearing in an upcoming issue of the Journal of Alzheimer’s Disease, published by IOS Press, entitled "Quantitative proteomics of cerebrospinal fluid from patients with Alzheimer disease," may lead to a new test for diagnosing the devastating illness. About 4 million Americans suffer from Alzheimer’s disease, the most common form of dementia, characterized by memory loss and an inability to use language.
"The study identified 40 times more proteins in human spinal fluid than previously known," said Drs. Thomas Montine and Jing Zhang, co-authors of the study and neuropathologists at Harborview Medical Center and the University of Washington. Montine is a UW professor of neuropathology and Zhang is a UW assistant professor of pathology. "As a result, we hope to be able to develop a much more thorough and robust test for diagnosing and predicting the progression of Alzheimer’s disease," said Montine.
The study employed a proteomic method developed at the University of Washington and the Institute for Systems Biology in Seattle. It identified more than 400 proteins in human spinal fluid, up to 40 times more proteins than identified by previous research models. On average, one of every five proteins identified was substantially changed in patients with Alzheimer’s disease compared to older people without neurologic disease. This roster of changed proteins will serve as a platform to develop specific biomarker panels for Alzheimer’s disease and other geriatric dementias.
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Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
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A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
Researchers from the University of Miami (UM) Rosenstiel School of Marine and Atmospheric Science, the Italian Space Agency (ASI), and the Instituto Geofisico--Escuela Politecnica Nacional (IGEPN) of Ecuador, showed an increasing volcanic danger on Cotopaxi in Ecuador using a powerful technique known as Interferometric Synthetic Aperture Radar (InSAR).
The Andes region in which Cotopaxi volcano is located is known to contain some of the world's most serious volcanic hazard. A mid- to large-size eruption has...
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