Novel anti-cancer compounds called Enigmols suppress the growth of human cell lines representing cancers of the prostate, breast, colon, ovary, pancreas, brain and blood, and reduce tumors in three animal studies, new research shows.
Enigmols cause the disappearance of nuclear beta-catenin, restoring cells to their normal behavior. Image Courtesy of Al Merrill
In addition, Enigmols did not show side effects at effective doses, according to the research conducted at the Georgia Institute of Technology, Emory University and Wayne State University. The studies were funded by the National Cancer Institute.
"Many agents suppress cancer cells in a Petri dish and then not in the whole animal, or have unacceptably high toxicity for normal tissues," said Georgia Tech Professor of Biology Al Merrill. "Finding that Enigmols are effective in three animal models leads us to hope these may be a new approach to treat cancer." However, human trials must still be done to determine safety and efficacy in people, the researchers cautioned.
Jane M. Sanders | EurekAlert!
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