Scientists have discovered that chemical signals thought to function primarily as cellular traffic directors play a much more complex role in the activation of the adaptive immune response than was previously expected. The research, published in the April issue of Immunity, demonstrates that the molecules belonging to a class of proteins called chemokines do more than simply guide migration of the immune cells that are activated in the very early stages of infection.
Dendritic cells (DCs) are present in tissues that are closely associated with the external environment. DCs function as a kind of sentinel for the immune system, constantly sampling their surroundings for potentially harmful pathogens. Once they encounter a bacteria or virus, the DCs mature and migrate from the periphery to lymphoid tissues where they activate T cells, critical immune cells that are essential to the immune response.
Chemokines are molecules that have been shown to direct the migration of DCs and recent research has indicated that they may also play a role in DC maturation. Dr. Martin F. Bachman from Cytos Biotechnology in Switzerland and colleagues were interested in identifying new proteins that might indirectly govern T cell responses through activation of DCs.
Researchers identify potentially druggable mutant p53 proteins that promote cancer growth
09.12.2016 | Cold Spring Harbor Laboratory
Plant-based substance boosts eyelash growth
09.12.2016 | Fraunhofer-Institut für Angewandte Polymerforschung IAP
Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.
Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
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