Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Chemokines orchestrate more than migration for immune cells

20.04.2005


Scientists have discovered that chemical signals thought to function primarily as cellular traffic directors play a much more complex role in the activation of the adaptive immune response than was previously expected. The research, published in the April issue of Immunity, demonstrates that the molecules belonging to a class of proteins called chemokines do more than simply guide migration of the immune cells that are activated in the very early stages of infection.



Dendritic cells (DCs) are present in tissues that are closely associated with the external environment. DCs function as a kind of sentinel for the immune system, constantly sampling their surroundings for potentially harmful pathogens. Once they encounter a bacteria or virus, the DCs mature and migrate from the periphery to lymphoid tissues where they activate T cells, critical immune cells that are essential to the immune response.

Chemokines are molecules that have been shown to direct the migration of DCs and recent research has indicated that they may also play a role in DC maturation. Dr. Martin F. Bachman from Cytos Biotechnology in Switzerland and colleagues were interested in identifying new proteins that might indirectly govern T cell responses through activation of DCs.


The researchers found that the chemokines CCL19 and CCL21 induced maturation of activated DCs and a subsequent upregulation of potent stimulatory molecules that enhanced T cell proliferation. Mice that lack CCL19/CCL21 had only partially activated DCs even when the DCs were activated by pathogen signals, suggesting that the chemokines are required for full maturation of DCs and proper activation of T cells.

"These findings indicate that induction of DC maturation is an important property of CCL19/CCL21 and suggest that chemokines may not only organize the migration of DCs but also directly regulate their ability to prime T cell responses," writes Dr. Bachmann. A clear understanding of the influence of these chemokines on T cell immune responses will be useful for rational design of future antiviral and anticancer therapies.

Heidi Hardman | EurekAlert!
Further information:
http://www.immunity.com
http://www.cell.com

More articles from Life Sciences:

nachricht Researchers identify potentially druggable mutant p53 proteins that promote cancer growth
09.12.2016 | Cold Spring Harbor Laboratory

nachricht Plant-based substance boosts eyelash growth
09.12.2016 | Fraunhofer-Institut für Angewandte Polymerforschung IAP

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>