St. Jude Childrens Research Hospital discovery of genetic links to multi-drug resistance gives clinicians new insight into the cause of treatment failure and suggests targets for novel anti-leukemic drugs
The discovery of a specific pattern of gene expression linked to multiple-drug resistance of leukemic cells is giving researchers crucial information into why standard therapies fail to cure some children with acute lymphoblastic leukemia (ALL). This finding, from investigators at St. Jude Childrens Research Hospital, could lead to development of drugs that would overcome that resistance.
This new finding helps to explain why about 20 percent of children with ALL, the most common form of childhood cancer, are not cured with the same drug therapy that cures the remaining 80 percent of children with this disease. A report on the study that produced this new information appears in the April issue of Cancer Cell.
Carrie Strehlau | EurekAlert!
Further information:
http://www.stjude.org
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