Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Variant in gene associated with telomeres predicts longer survival of deadly brain tumor

19.04.2005


An exceptionally large study of patients with glioblastoma multiforme has found an association between a genetic variation and a doubling of survival rate - the strongest link ever established between genetic variation and outcome in this deadliest form of brain cancer, according to researchers at The University of Texas M. D. Anderson Cancer Center.



The study, presented at the annual meeting of the American Association of Cancer Research, found the differences in a common variant in a number of repeats (short or long) of the hTERT gene, which produces human telomerase.

This study of 301 patients, which the researchers believe is the largest to date of patients with glioblastoma multiforme, found that the 36 patients (about 11 percent) who had the "SS" variant genotype of hTERT survived an average of 25 months, compared to about 14 months for those who had either the "SL" or "LL" genotypes.


The findings are exciting, says the lead investigator, Melissa Bondy, Ph.D., a professor in the Department of Epidemiology, because they suggest new treatment directions for patients with a cancer that is both the most common glioma and the one offering the poorest hope of survival.

"It is a real advance because we have never seen any genotype that can stratify glioblastoma multiforme patients into different treatment outcome groups like this," says Bondy. "Now we need to verify the finding, study the mechanism, and see if there is a way that these results can be used either as a biomarker or to individualize treatment."

For example, if the SS variant genotype of hTERT is confirmed to have better response to chemotherapy and radiation treatment, then it is possible that these therapies will extend survival for patients with glioblastoma multiforme, she says.

Telomeres, the structures that cap the end of cellular chromosomes, have been linked to both the aging process and cancer development. Telomerase is an enzyme that helps regulate the length of telomeres, and in normal cells, it is not generally active past fetal development. Thus, telomeres shorten each time a cell divides, until they cannot protect chromosomes and the cell dies. But in cancer, it is believed that telomerase is activated and intervenes to keep telomeres from shortening, allowing for unlimited cell division.

The research group looked at genetic variation of hTERT because abnormal expression of the gene contributes to unregulated cell growth, and expression of the gene has been evaluated as one of the most common tumor markers in most primary tumors, says the study’s first author, Luo Wang, M.D., Ph.D., a research scientist in the Department of Epidemiology.

The mechanism why the SS variant genotype of hTERT showed better survival remains unknown. But some forms of hTERT may be less destructive than others because they may be expressed at a lower level, Wang says. For instance, the SS variant genotype is more likely than the SL or LL variant genotype to produce an antisense-like molecule that suppresses the expression of human telomerase, he says, and this modulation may enhance the effect of the chemotherapy and radiation treatment on the patients with the SS variant genotype.

Bondy says the association between the SS variant genotype and improved outcome held, even when differences in age, sex and the extent of surgery, chemotherapy and radiation were taken into account. "We have looked at a lot of different genes associated with cancer, such as DNA repair genes and p53, but this is the first time we have found a genotype that has such a large effect on clinical outcome."

Nancy Jensen | EurekAlert!
Further information:
http://www.mdanderson.org

More articles from Life Sciences:

nachricht A new technique isolates neuronal activity during memory consolidation
22.06.2017 | Spanish National Research Council (CSIC)

nachricht CWRU researchers find a chemical solution to shrink digital data storage
22.06.2017 | Case Western Reserve University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

Im Focus: Optoelectronic Inline Measurement – Accurate to the Nanometer

Germany counts high-precision manufacturing processes among its advantages as a location. It’s not just the aerospace and automotive industries that require almost waste-free, high-precision manufacturing to provide an efficient way of testing the shape and orientation tolerances of products. Since current inline measurement technology not yet provides the required accuracy, the Fraunhofer Institute for Laser Technology ILT is collaborating with four renowned industry partners in the INSPIRE project to develop inline sensors with a new accuracy class. Funded by the German Federal Ministry of Education and Research (BMBF), the project is scheduled to run until the end of 2019.

New Manufacturing Technologies for New Products

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

A new technique isolates neuronal activity during memory consolidation

22.06.2017 | Life Sciences

Plant inspiration could lead to flexible electronics

22.06.2017 | Materials Sciences

A rhodium-based catalyst for making organosilicon using less precious metal

22.06.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>