Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Melbourne researchers develop safer and more effective "aspirin"


Monash University researchers and staff of the Melbourne-based biotechnology company Cerylid Biosciences Ltd, have discovered and developed a new class of anti-clotting drugs that appears to be more effective than aspirin at preventing disease-causing blood clots and has fewer side effects.

Heart attack and stroke are the leading cause of death and disability in the western world and result in the death of about 50,000 Australians each year.

They are typically caused by blood clots that block blood flow to the heart or brain. Patients (except those stroke patients whose illness is caused by bleeding into the brain) are usually treated with aspirin, but this can increase the risk of bleeding and lead to life-threatening haemorrhages.

Associate Professor Shaun Jackson (pictured), from the Australian Centre for Blood Diseases at Monash, said this new class of drugs, called PI 3-kinase inhibitors, may prove to be vitally important in treating heart attack and stroke patients by stopping formation of the problem-causing blood clots without causing excessive bleeding.

"Aspirin is the most widely used anti-clotting drug , however it is only effective at preventing fatal heart attack and stroke for about one in four patients," Dr Jackson said. "There is a major need for safer and more effective anti-clotting drugs. The ’holy grail’ in the field is a drug that prevents disease-causing clots whilst not increasing the risk of bleeding."

Animal studies have shown that the drugs, developed by Dr Jackson and colleagues at the Department of Pharmacology at the University of Melbourne, Cerylid Biosciences and the University College of London, do not increase the risk of bleeding.

Phase I trials in human volunteers have also yielded promising results.

The drugs were developed after Dr Jackson and colleagues identified the mechanism that promotes the formation of pathological blood clots (clots that lead to heart attack or stroke) and how it differed from the mechanisms involved in normal blood clotting.

Their research is published today in the international journal Nature Medicine.

Dr Jackie Fairley, CEO of Cerylid Biosciences, said it was too early to say if the drugs would replace aspirin in treating heart attack and stroke but that at this stage in their development, they had enormous potential.

Commercial rights to these anti-thrombotic compounds are held by Cerylid Biosciences. The company, which holds a number of patents over the compounds and associated technology, will take its second-generation PI3-kinase inhibitor, CBL1309, into clinical trials later this year.

For more information contact: Monash University -- Ms Penny Fannin on +61 3 9905 5828 or 0417 125 700. Cerylid Biosciences -- Ms Rebecca Christie, Buchan Consulting, 0417 382 391

Penny Fannin | EurekAlert!
Further information:

More articles from Life Sciences:

nachricht Two decades of training students and experts in tracking infectious disease
27.11.2015 | Hochschule für Angewandte Wissenschaften Hamburg

nachricht Increased carbon dioxide enhances plankton growth, opposite of what was expected
27.11.2015 | Bigelow Laboratory for Ocean Sciences

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Climate study finds evidence of global shift in the 1980s

Planet Earth experienced a global climate shift in the late 1980s on an unprecedented scale, fuelled by anthropogenic warming and a volcanic eruption, according to new research published this week.

Scientists say that a major step change, or ‘regime shift’, in the Earth’s biophysical systems, from the upper atmosphere to the depths of the ocean and from...

Im Focus: Innovative Photovoltaics – from the Lab to the Façade

Fraunhofer ISE Demonstrates New Cell and Module Technologies on its Outer Building Façade

The Fraunhofer Institute for Solar Energy Systems ISE has installed 70 photovoltaic modules on the outer façade of one of its lab buildings. The modules were...

Im Focus: Lactate for Brain Energy

Nerve cells cover their high energy demand with glucose and lactate. Scientists of the University of Zurich now provide new support for this. They show for the first time in the intact mouse brain evidence for an exchange of lactate between different brain cells. With this study they were able to confirm a 20-year old hypothesis.

In comparison to other organs, the human brain has the highest energy requirements. The supply of energy for nerve cells and the particular role of lactic acid...

Im Focus: Laser process simulation available as app for first time

In laser material processing, the simulation of processes has made great strides over the past few years. Today, the software can predict relatively well what will happen on the workpiece. Unfortunately, it is also highly complex and requires a lot of computing time. Thanks to clever simplification, experts from Fraunhofer ILT are now able to offer the first-ever simulation software that calculates processes in real time and also runs on tablet computers and smartphones. The fast software enables users to do without expensive experiments and to find optimum process parameters even more effectively.

Before now, the reliable simulation of laser processes was a job for experts. Armed with sophisticated software packages and after many hours on computer...

Im Focus: Quantum Simulation: A Better Understanding of Magnetism

Heidelberg physicists use ultracold atoms to imitate the behaviour of electrons in a solid

Researchers at Heidelberg University have devised a new way to study the phenomenon of magnetism. Using ultracold atoms at near absolute zero, they prepared a...

All Focus news of the innovation-report >>>



Event News

Fraunhofer’s Urban Futures Conference: 2 days in the city of the future

25.11.2015 | Event News

Gluten oder nicht Gluten? Überempfindlichkeit auf Weizen kann unterschiedliche Ursachen haben

17.11.2015 | Event News

Art Collection Deutsche Börse zeigt Ausstellung „Traces of Disorder“

21.10.2015 | Event News

Latest News

Siemens to supply 126 megawatts to onshore wind power plants in Scotland

27.11.2015 | Press release

Two decades of training students and experts in tracking infectious disease

27.11.2015 | Life Sciences

Coming to a monitor near you: A defect-free, molecule-thick film

27.11.2015 | Materials Sciences

More VideoLinks >>>