Understanding the interaction of Fragile X mental retardation protein and kissing complex RNAs
Fragile X syndrome is the most common inherited form of mental retardation, affecting approximately 1 in 3600 males and 1 in 4000-6000 females. Fragile X syndrome results from loss of expression of the Fragile X mental retardation protein (FMRP), the product of the FMR1 gene. Now, Drs. Robert and Jennifer Darnell and colleagues, from The Rockefeller University, report the uncovering of a new interaction between FMRP and messenger RNAs (mRNAs) containing a tertiary RNA structure termed a "kissing complex".
Their studies, published in the April 15th issue of Genes & Development, provide a new direction for efforts to understand how the loss of FMRP function leads to the complex behavioral and cognitive defects characteristic of Fragile X syndrome.
While the importance of identifying a function for FMRP has been clear for some time, what this function actually is has continued to evade researchers. FMRP is a protein characterized by the presence of three RNA binding domains: two tandem KH-type RNA binding domains and an RGG box. Scientists have focused on the identification of FMRP RNA ligands in an effort to understand FMRP function. This effort is particularly meaningful since FMRP is believed to regulate mRNA translation in the brain, and identifying the mRNA targets of this regulation would be a huge step in understanding how loss of this protein results in the varied and complex phenotypes of Fragile X syndrome.
Heather Cosel | EurekAlert!
Water forms 'spine of hydration' around DNA, group finds
26.05.2017 | Cornell University
How herpesviruses win the footrace against the immune system
26.05.2017 | Helmholtz-Zentrum für Infektionsforschung
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy