When Michael Oshinsky, Ph.D., gives his rats a headache, he has good reason.
The animals are helping Dr. Oshinsky, assistant professor of neurology at Jefferson Medical College of Thomas Jefferson University in Philadelphia, study how migraine treatments work. In recent experiments, the animals provided evidence showing that DHE, a standard drug currently used to treat acute migraine pain can also work against the onset of a phenomenon called "central sensitization," or "allodynia," which involves, as most migraine sufferers know, a heightened sensitivity to touch. He presents his findings April 12, 2005 at the annual meeting of the American Academy of Neurology in Miami Beach.
For many migraine sufferers, it hurts to touch their face, brush their hair, even take a shower during a migraine attack. Triptans, another class of drugs commonly used to treat migraines, can also treat acute headache pain, but has a narrow window in which it works against allodynia. Dr. Oshinsky looked at DHEs effectiveness on halting or lessening this secondary effect.
Steve Benowitz | EurekAlert!
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